TY  - JOUR
A1  - Diez-Perez, Adolfo
A1  - Brandi, Maria Luisa
A1  - Al‑Daghri, Nasser
A1  - Branco, Jaime C.
A1  - Bruyère, Olivier
A1  - Cavalli, Loredana
A1  - Cooper, Cyrus
A1  - Cortet, Bernard
A1  - Dawson-Hughes, Bess
A1  - Dimai, Hans Peter
A1  - Gonnelli, Stefano
A1  - Hadji, Peyman
A1  - Halbout, Philippe
A1  - Kaufman, Jean‑Marc
A1  - Kurth, Andreas Alois
A1  - Locquet, Medea
A1  - Maggi, Stefania
A1  - Matijevic, Radmila
A1  - Reginster, Jean‑Yves
A1  - Rizzoli, René
A1  - Thierry, Thomas
T1  - Radiofrequency echographic multi-spectrometry for the in-vivo assessment of bone strength: state of the art—outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)
T2  - Aging clinical and experimental research
N2  - Purpose: The purpose of this paper was to review the available approaches for bone strength assessment, osteoporosis diagnosis and fracture risk prediction, and to provide insights into radiofrequency echographic multi spectrometry (REMS), a non-ionizing axial skeleton technique.
Methods: A working group convened by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis met to review the current image-based methods for bone strength assessment and fracture risk estimation, and to discuss the clinical perspectives of REMS.
Results: Areal bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) is the consolidated indicator for osteoporosis diagnosis and fracture risk assessment. A more reliable fracture risk estimation would actually require an improved assessment of bone strength, integrating also bone quality information. Several different approaches have been proposed, including additional DXA-based parameters, quantitative computed tomography, and quantitative ultrasound. Although each of them showed a somewhat improved clinical performance, none satisfied all the requirements for a widespread routine employment, which was typically hindered by unclear clinical usefulness, radiation doses, limited accessibility, or inapplicability to spine and hip, therefore leaving several clinical needs still unmet. REMS is a clinically available technology for osteoporosis diagnosis and fracture risk assessment through the estimation of BMD on the axial skeleton reference sites. Its automatic processing of unfiltered ultrasound signals provides accurate BMD values in view of fracture risk assessment.
Conclusions: New approaches for improved bone strength and fracture risk estimations are needed for a better management of osteoporotic patients. In this context, REMS represents a valuable approach for osteoporosis diagnosis and fracture risk prediction.
KW  - Bone strength assessment
KW  - Osteoporosis diagnosis
KW  - Fracture risk
KW  - REMS
KW  - Ultrasound
KW  - Lumbar spine
KW  - Femoral neck
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/53419
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-534194
SN  - 1720-8319
SN  - 1594-0667
N1  - Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
VL  - 31
IS  - 10
SP  - 1375
EP  - 1389
PB  - Springer
CY  - Berlin ; Heidelberg
ER  -