TY  - JOUR
A1  - Tomko, Matus
A1  - Benuskova, Lubica
A1  - Jedlička, Peter
T1  - A new reduced-morphology model for CA1 pyramidal cells and its validation and comparison with other models using HippoUnit
T2  - Scientific reports
N2  - Modeling long-term neuronal dynamics may require running long-lasting simulations. Such simulations are computationally expensive, and therefore it is advantageous to use simplified models that sufficiently reproduce the real neuronal properties. Reducing the complexity of the neuronal dendritic tree is one option. Therefore, we have developed a new reduced-morphology model of the rat CA1 pyramidal cell which retains major dendritic branch classes. To validate our model with experimental data, we used HippoUnit, a recently established standardized test suite for CA1 pyramidal cell models. The HippoUnit allowed us to systematically evaluate the somatic and dendritic properties of the model and compare them to models publicly available in the ModelDB database. Our model reproduced (1) somatic spiking properties, (2) somatic depolarization block, (3) EPSP attenuation, (4) action potential backpropagation, and (5) synaptic integration at oblique dendrites of CA1 neurons. The overall performance of the model in these tests achieved higher biological accuracy compared to other tested models. We conclude that, due to its realistic biophysics and low morphological complexity, our model captures key physiological features of CA1 pyramidal neurons and shortens computational time, respectively. Thus, the validated reduced-morphology model can be used for computationally demanding simulations as a substitute for more complex models.
KW  - Biophysical models
KW  - Computational models
KW  - Computational neuroscience
KW  - Computational science
KW  - Computer science
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63643
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-636438
SN  - 2045-2322
N1  - We acknowledge the financial support from the National Scholarship Programme of the Slovak Republic provided by the Slovak Academic Information Agency (SAIA) to M.T. This work was supported by BMBF (No. 031L0229—HUMANEUROMOD) to P.J.
N1  - The datasets generated during and analyzed during the current study are available in the GitHub repository, https://github.com/tomko-neuron/HippoUnit.
VL  - 11
IS  - 111765
SP  - 1
EP  - 16
PB  - Macmillan Publishers Limited, part of Springer Nature
CY  - [London]
ER  -