TY  - JOUR
A1  - Castro, André Ferreira
A1  - Baltruschat, Lothar Gunnar
A1  - Stürner, Tomke
A1  - Bahrami, Amirhoushang
A1  - Jedlička, Peter
A1  - Tavosanis, Gaia
A1  - Cuntz, Hermann
T1  - Achieving functional neuronal dendrite structure through sequential stochastic growth and retraction
T2  - eLife
N2  - Class I ventral posterior dendritic arborisation (c1vpda) proprioceptive sensory neurons respond to contractions in the Drosophila larval body wall during crawling. Their dendritic branches run along the direction of contraction, possibly a functional requirement to maximise membrane curvature during crawling contractions. Although the molecular machinery of dendritic patterning in c1vpda has been extensively studied, the process leading to the precise elaboration of their comb-like shapes remains elusive. Here, to link dendrite shape with its proprioceptive role, we performed long-term, non-invasive, in vivo time-lapse imaging of c1vpda embryonic and larval morphogenesis to reveal a sequence of differentiation stages. We combined computer models and dendritic branch dynamics tracking to propose that distinct sequential phases of stochastic growth and retraction achieve efficient dendritic trees both in terms of wire and function. Our study shows how dendrite growth balances structure–function requirements, shedding new light on general principles of self-organisation in functionally specialised dendrites.
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/73394
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-733942
SN  - 2050-084X
VL  - 9
IS  - e60920
PB  - eLife Sciences Publications
CY  - Cambridge
ER  -