TY  - JOUR
A1  - Paithankar, Karthik Shivaji
A1  - Enderle, Mathias
A1  - Wirthensohn, David C.
A1  - Miller, Arthur
A1  - Schlesner, Matthias
A1  - Pfeiffer, Friedhelm
A1  - Rittner, Alexander
A1  - Grininger, Martin
A1  - Oesterhelt, Dieter
T1  - Structure of the archaeal chemotaxis protein CheY in a domain-swapped dimeric conformation
T2  - Acta crystallographica. Section F, Structural biology communications
N2  - Archaea are motile by the rotation of the archaellum. The archaellum switches between clockwise and counterclockwise rotation, and movement along a chemical gradient is possible by modulation of the switching frequency. This modulation involves the response regulator CheY and the archaellum adaptor protein CheF. In this study, two new crystal forms and protein structures of CheY are reported. In both crystal forms, CheY is arranged in a domain-swapped conformation. CheF, the protein bridging the chemotaxis signal transduction system and the motility apparatus, was recombinantly expressed, purified and subjected to X-ray data collection.
KW  - chemotaxis
KW  - signal transduction
KW  - response regulator
KW  - CheY
KW  - CheF
KW  - archaellum
KW  - protein evolution
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/53082
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-530826
SN  - 2053-230X
SN  - 1744-3091
N1  - This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
VL  - 75
IS  - 9
SP  - 576
EP  - 585
PB  - Blackwell
CY  - Oxford [u. a.]
ER  -