TY - INPR A1 - Aru, Juhan A1 - Aru, Jaan A1 - Priesemann, Viola A1 - Wibral, Michael A1 - Lana, Luiz A1 - Pipa, Gordon A1 - Singer, Wolf A1 - Vicente, Raul T1 - Untangling cross-frequency coupling in neuroscience T2 - bioRxiv N2 - Cross-frequency coupling (CFC) has been proposed to coordinate neural dynamics across spatial and temporal scales. Despite its potential relevance for understanding healthy and pathological brain function, the standard CFC analysis and physiological interpretation come with fundamental problems. For example, apparent CFC can appear because of spectral correlations due to common non-stationarities that may arise in the total absence of interactions between neural frequency components. To provide a road map towards an improved mechanistic understanding of CFC, we organize the available and potential novel statistical/modeling approaches according to their biophysical interpretability. While we do not provide solutions for all the problems described, we provide a list of practical recommendations to avoid common errors and to enhance the interpretability of CFC analysis. Y1 - 2014 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/72372 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-723729 IS - 005926 ER -