TY  - JOUR
A1  - Maurer, Gabriele D.
A1  - Tichy, Julia Frederike
A1  - Harter, Patrick Nikolaus
A1  - Nöth, Ulrike
A1  - Weise, Lutz
A1  - Quick-Weller, Johanna
A1  - Deichmann, Ralf
A1  - Steinbach, Joachim Peter
A1  - Bähr, Roy Oliver
A1  - Hattingen, Elke
T1  - Matching quantitative MRI parameters with histological features of treatment-naïve IDH wild-type glioma
T2  - Cancers
N2  - Quantitative MRI allows to probe tissue properties by measuring relaxation times and may thus detect subtle changes in tissue composition. In this work we analyzed different relaxation times (T1, T2, T2* and T2′) and histological features in 321 samples that were acquired from 25 patients with newly diagnosed IDH wild-type glioma. Quantitative relaxation times before intravenous application of gadolinium-based contrast agent (GBCA), T1 relaxation time after GBCA as well as the relative difference between T1 relaxation times pre-to-post GBCA (T1rel) were compared with histopathologic features such as the presence of tumor cells, cell and vessel density, endogenous markers for hypoxia and cell proliferation. Image-guided stereotactic biopsy allowed for the attribution of each tissue specimen to its corresponding position in the respective relaxation time map. Compared to normal tissue, T1 and T2 relaxation times and T1rel were prolonged in samples containing tumor cells. The presence of vascular proliferates was associated with higher T1rel values. Immunopositivity for lactate dehydrogenase A (LDHA) involved slightly longer T1 relaxation times. However, low T2′ values, suggesting high amounts of deoxyhemoglobin, were found in samples with elevated vessel densities, but not in samples with increased immunopositivity for LDHA. Taken together, some of our observations were consistent with previous findings but the correlation of quantitative MRI and histologic parameters did not confirm all our pathophysiology-based assumptions.
KW  - quantitative MRI
KW  - glioblastoma
KW  - image-guided tissue acquisition
KW  - hypoxia
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62657
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-626572
SN  - 2072-6694
N1  - The project was funded by a young investigator grant to J.T. from the Faculty of Medicine, Goethe University Frankfurt (Patenschaftsmodell). The Senckenberg Institute of Neurooncology was supported by the Senckenberg foundation (grant number 2014/SIN-02).
VL  - 13
IS  - 16, art. 4060
SP  - 1
EP  - 13
PB  - MDPI
CY  - Basel
ER  -