TY  - JOUR
A1  - Hofmann, Matthias
A1  - Pflanzer, Ralph
A1  - Zöller, Nadja Nicole
A1  - Bernd, August
A1  - Kaufmann, Roland
A1  - Thaçi, Diamant
A1  - Bereiter-Hahn, Jürgen
A1  - Hirohata, Satoshi
A1  - Kippenberger, Stefan
T1  - Vascular endothelial growth factor C-induced lymphangiogenesis decreases tumor interstitial fluid pressure and tumor
T2  - Translational oncology
N2  - Characteristically, most solid tumors exhibit an increased tumor interstitial fluid pressure (TIFP) that directly contributes to the lowered uptake of macromolecular therapeutics into the tumor interstitium. Abnormalities in the tumor-associated lymph vessels are a central brick in the development and prolonged sustaining of an increased TIFP. In the current study, vascular endothelial growth factor C (VEGF-C) was used to enhance tumor-associated lymphangiogenesis as a new mechanism to actively reduce the TIFP by increased lymphatic drainage of the tumor tissue. Human A431 epidermoid vulva carcinoma cells were inoculated in NMRI nu/nu mice to generate a xenograft mouse model. Seven days after tumor cell injection, VEGF-C was peritumorally injected to induce lymphangiogenesis. Tumor growth and TIFP was lowered significantly over time in VEGF-C-treated tumors in comparison to control or VEGF-A-treated animals. These data demonstrate for the first time that actively induced lymphangiogenesis can lower the TIFP in a xenograft tumor model and apparently reduce tumor growth. This model represents a novel approach to modulate biomechanical properties of the tumor interstitium enabling a lowering of TIFP in vivo.
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/76882
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-768825
SN  - 1936-5233
VL  - 6.2013
IS  - 4
SP  - 398
EP  - 404
PB  - Neoplasia Press, Inc.
ER  -