TY  - JOUR
A1  - Obermeier, Martin
A1  - Berg, Thomas
A1  - Sichtig, Nadine
A1  - Braun, Patrick
A1  - Däumer, Martin P.
A1  - Walter, Hauke
A1  - Noah, Christian
A1  - Wolf, Eva
A1  - Müller, Harm
A1  - Stürmer, Martin
A1  - Thielen, Alexander
A1  - Kaiser, Rolf
T1  - Determination of HIV-1 co-receptor usage in German patients : comparison of genotypic methods with the TROFILE® phenotypic assay
T2  - Journal of the International AIDS Society ; from Ninth International Congress on Drug Therapy in HIV Infection Glasgow, UK. 9–13 November 2008
N2  - Poster presentation: Background Maraviroc is a new drug used to treat HIV infection from the new class of drugs called CCR5 entry inhibitors. As the active principle of these drugs is to block the CCR5-receptor on the surface of the target cells, it has to be known if the virus in the patient is using only CCR5 as co-receptor or if there are populations that can also use CXCR4. Therefore, an assay to determine the tropism has to be performed before starting a therapy. Besides phenotypic assays like the TROFILE® assay by Monogram, used in the approval studies, there exist several genotyping systems like geno2pheno-coreceptor, Wetcat (providing five different genotypic tropism schemes) and WebPSSM. ...
Y1  - 2008
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/7057
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-70719
N1  - © 2008 Obermeier et al; licensee BioMed Central Ltd.
VL  - 11
IS  - (Suppl 1):P201
ER  -