TY  - JOUR
A1  - Marenholz, Ingo
A1  - Grosche, Sarah
A1  - Kalb, Birgit
A1  - Rüschendorf, Franz
A1  - Blümchen, Katharina
A1  - Schlags, Rupert
A1  - Harandi, Neda
A1  - Price, Mareike
A1  - Hansen, Gesine
A1  - Seidenberg, Jürgen
A1  - Röblitz, Holger
A1  - Yürek, Songül
A1  - Tschirner, Sebastian
A1  - Hong, Xiumei
A1  - Wang, Xiaobin
A1  - Homuth, Georg
A1  - Schmidt, Carsten
A1  - Nöthen, Markus Maria
A1  - Hübner, Norbert
A1  - Niggemann, Bodo
A1  - Beyer, Kirsten
A1  - Lee, Young-Ae
T1  - Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy
T2  - Nature Communications
N2  - Genetic factors and mechanisms underlying food allergy are largely unknown. Due to heterogeneity of symptoms a reliable diagnosis is often difficult to make. Here, we report a genome-wide association study on food allergy diagnosed by oral food challenge in 497 cases and 2387 controls. We identify five loci at genome-wide significance, the clade B serpin (SERPINB) gene cluster at 18q21.3, the cytokine gene cluster at 5q31.1, the filaggrin gene, the C11orf30/LRRC32 locus, and the human leukocyte antigen (HLA) region. Stratifying the results for the causative food demonstrates that association of the HLA locus is peanut allergy-specific whereas the other four loci increase the risk for any food allergy. Variants in the SERPINB gene cluster are associated with SERPINB10 expression in leukocytes. Moreover, SERPINB genes are highly expressed in the esophagus. All identified loci are involved in immunological regulation or epithelial barrier function, emphasizing the role of both mechanisms in food allergy.
KW  - Allergy
KW  - Genome-wide association studies
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/46966
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-469661
SN  - 2041-1723
N1  - Rights and permissions: Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
VL  - 8
IS  - 1, Art. 1056
SP  - 1
EP  - 10
PB  - Nature Publishing Group UK
CY  - [London]
ER  -