TY  - JOUR
A1  - Vaidya, Aishwarya R.
A1  - Wolska, Nina
A1  - Vara, Dina
A1  - Mailer, Reiner Karl Walter
A1  - Schröder, Katrin
A1  - Pula, Giordano
T1  - Diabetes and thrombosis: a central role for vascular oxidative stress
T2  - Antioxidants
N2  - Diabetes mellitus is the fifth most common cause of death worldwide. Due to its chronic nature, diabetes is a debilitating disease for the patient and a relevant cost for the national health system. Type 2 diabetes mellitus is the most common form of diabetes mellitus (90% of cases) and is characteristically multifactorial, with both genetic and environmental causes. Diabetes patients display a significant increase in the risk of developing cardiovascular disease compared to the rest of the population. This is associated with increased blood clotting, which results in circulatory complications and vascular damage. Platelets are circulating cells within the vascular system that contribute to hemostasis. Their increased tendency to activate and form thrombi has been observed in diabetes mellitus patients (i.e., platelet hyperactivity). The oxidative damage of platelets and the function of pro-oxidant enzymes such as the NADPH oxidases appear central to diabetes-dependent platelet hyperactivity. In addition to platelet hyperactivity, endothelial cell damage and alterations of the coagulation response also participate in the vascular damage associated with diabetes. Here, we present an updated interpretation of the molecular mechanisms underlying vascular damage in diabetes, including current therapeutic options for its control.
KW  - diabetes
KW  - oxidative stress
KW  - platelet hyperactivity
KW  - NADPH oxidase
KW  - NFkB
KW  - thrombosis
KW  - fibrinolysis
KW  - endothelial dysfunction
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62123
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-621239
SN  - 2076-3921
N1  - This work was funded by British Heart Foundation (PG/15/40/31522), Alzheimer’s Research UK (ARUK-PG2017A-3), and Werner Otto Foundation (#3/97) grants to Giordano Pula, and DFG grants (CRC815 TPA1 and SFB834 TPA2) to Katrin Schröder. Nina Wolska was supported by an ETIUDA7 doctoral scholarship funded by the National Science Centre, Poland (2019/32/T/NZ3/00333).
VL  - 10
IS  - 5, art. 706
SP  - 1
EP  - 12
PB  - MDPI
CY  - Basel
ER  -