TY  - JOUR
A1  - Tsalouchidou, Panagiota-Eleni
A1  - Mintziras, Ioannis
A1  - Biermann, Louise
A1  - Krause, Kristina
A1  - Bergmann, Marc-Philipp
A1  - Belke, Marcus
A1  - Nimsky, Christopher
A1  - Schulze, Maximilian
A1  - Strzelczyk, Adam
A1  - Rosenow, Felix
A1  - Menzler, Katja
A1  - Knake, Susanne
T1  - Temporal encephaloceles in epilepsy patients and asymptomatic cases: size may indicate epileptogenicity
T2  - Epilepsia
N2  - Objective: This study was undertaken to identify temporal encephaloceles (TEs) and examine their characteristics in patients with temporal lobe epilepsy (TLE) and ex- tratemporal lobe epilepsy (ETLE), as well as in asymptomatic cases.
Methods: Four hundred fifty-eight magnetic resonance imaging scans were exam- ined retrospectively to identify TE in 157 patients with TLE, 150 patients with ETLE, and 151 healthy controls (HCs).
Results: At least one TE was identified in 9.6% of the TLE patients (n = 15, 95% confidence interval [CI] = 5.3%–15.3%), in 3.3% of patients with ETLE (n = 5, 95% CI = 1.1%–7.6%), and in 2.0% of the HCs (n = 3, 95% CI = .4%–5.7%), indicating a significantly higher frequency in patients with TLE compared to ETLE and HC sub- jects (p = .027, p = .005). Examining the characteristics of TEs in both asymptomatic and epilepsy patients, we found that TEs with a diameter of less than 6.25 mm were more likely to be asymptomatic, with a sensitivity of 91.7% and a specificity of 73.3% (area under the curve = .867, 95% CI = .723–1.00, p = .001).
Significance: Temporal encephaloceles may occur without presenting any clinical symp- toms. Patients with TLE show a higher frequency of TEs compared to the ETLE and HC groups. According to our study, TE size could be used to suggest potential epileptogenicity.
KW  - asymptomatic temporal encephaloceles
KW  - epilepsy surgery
KW  - MRI-negative epilepsy
KW  - temporal encephaloceles
KW  - temporal lobe epilepsy
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62093
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-620932
SN  - 1528-1167
VL  - 62
IS  - 6
SP  - 1354
EP  - 1361
PB  - Wiley-Blackwell
CY  - Oxford
ER  -