TY  - JOUR
A1  - Schiweck, Carmen
A1  - Aichholzer, Mareike
A1  - Reif, Andreas
A1  - Edwin Thanarajah, Sharmili
T1  - Targeting IL-17A signaling in suicidality, promise or the long arm of coincidence? Evidence in psychiatric populations revisited
T2  - Journal of affective disorders reports
N2  - Highlights
• Suicides which occurred in a biologics trial targeting the IL-17R are revisited.
• High IL-17 levels are found in depression by the majority of reports.
• Results from studies regarding IL-17 and psychosis are mixed.
• Very few psychiatric studies investigated IL-17 signalling in suicidality.
• Potential mechanisms how IL-17 influences neuro-inflammation are described.
Abstract:
Interleukin 17 (IL-17) is a potent pro-inflammatory cytokine which plays a role in autoimmune disorders, such as psoriasis and multiple sclerosis, and is important for the defense against pathogens, particularly in the gut. However, IL-17 has recently also gained attention in association with suicidal behavior. In this review, we review the literature regarding IL-17 in psychiatric disorders and suicidality. We also take a closer look at the suicides which occurred in the clinical trial for psoriasis with brodalumab, a monoclonal antibody targeting the IL-17 receptor. Lastly, we discuss potential working mechanisms relevant to neuroinflammation and the possible involvement of IL-17.
KW  - IL-17
KW  - Inflammation
KW  - Suicide
KW  - Depression
KW  - Brodalumab
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/77088
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-770881
SN  - 2666-9153
VL  - 11.2023
IS  - 100454
PB  - Elsevier
CY  - Amsterdam
ER  -