TY  - JOUR
A1  - Issa-Nummer, Yasmin
A1  - Darb-Esfahani, Silvia
A1  - Loibl, Sibylle
A1  - Kunz, Georg
A1  - Nekljudova, Valentina
A1  - Schrader, Iris
A1  - Sinn, Bruno Valentin
A1  - Ulmer, Hans-Ullrich
A1  - Kronenwett, Ralf
A1  - Just, Marianne
A1  - Kühn, Thorsten
A1  - Diebold, Kurt
A1  - Untch, Michael
A1  - Holms, Frank
A1  - Blohmer, Jens-Uwe
A1  - Habeck, Jörg-Olaf
A1  - Dietel, Manfred
A1  - Overkamp, Friedrich
A1  - Krabisch, Petra
A1  - Minckwitz, Gunter von
A1  - Denkert, Carsten Michael
T1  - Prospective validation of immunological infiltrate for prediction of response to neoadjuvant chemotherapy in HER2-negative breast cancer : a substudy of the neoadjuvant GeparQuinto trial
T2  - PLoS One
N2  - Introduction: We have recently described an increased lymphocytic infiltration rate in breast carcinoma tissue is a significant response predictor for anthracycline/taxane-based neoadjuvant chemotherapy (NACT). The aim of this study was to prospectively validate the tumor-associated lymphocyte infiltrate as predictive marker for response to anthracycline/taxane-based NACT.
Patients and Methods: The immunological infiltrate was prospectively evaluated in a total of 313 core biopsies from HER2 negative patients of the multicenter PREDICT study, a substudy of the neoadjuvant GeparQuinto study. Intratumoral lymphocytes (iTuLy), stromal lymphocytes (strLy) as well as lymphocyte-predominant breast cancer (LPBC) were evaluated by histopathological assessment. Pathological complete response (pCR) rates were analyzed and compared between the defined subgroups using the exact test of Fisher.
Results: Patients with lymphocyte-predominant breast cancer (LPBC) had a significantly increased pCR rate of 36.6%, compared to non-LPBC patients (14.3%, p<0.001). LPBC and stromal lymphocytes were significantly independent predictors for pCR in multivariate analysis (LPBC: OR 2.7, p = 0.003, strLy: OR 1.2, p = 0.01). The amount of intratumoral lymphocytes was significantly predictive for pCR in univariate (OR 1.2, p = 0.01) but not in multivariate logistic regression analysis (OR 1.2, p = 0.11).
Conclusion: Confirming previous investigations of our group, we have prospectively validated in an independent cohort that an increased immunological infiltrate in breast tumor tissue is predictive for response to anthracycline/taxane-based NACT. Patients with LPBC and increased stromal lymphocyte infiltration have significantly increased pCR rates. The lymphocytic infiltrate is a promising additional parameter for histopathological evaluation of breast cancer core biopsies.
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/32887
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-328874
SN  - 1932-6203
N1  - Copyright: © 2013 Issa-Nummer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/ , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 8
IS  - (12):e79775
PB  - PLoS
CY  - Lawrence, Kan.
ER  -