TY  - JOUR
A1  - Dovizio, Melania
A1  - Alberti, Sara
A1  - Sacco, Angela
A1  - Guillem-Llobat, Paloma
A1  - Schiavone, Simone
A1  - Maier, Thorsten Jürgen
A1  - Steinhilber, Dieter
A1  - Patrignani, Paola
T1  - Novel insights into the regulation of cyclooxygenase-2 expression by platelet-cancer cell cross-talk
T2  - Biochemical Society Transactions
N2  - Platelets are activated by the interaction with cancer cells and release enhanced levels of lipid mediators [such as thromboxane (TX)A2 and prostaglandin (PG)E2, generated from arachidonic acid (AA) by the activity of cyclooxygenase (COX)-1], granule content, including ADP and growth factors, chemokines, proteases and Wnt proteins. Moreover, activated platelets shed different vesicles, such as microparticles (MPs) and exosomes (rich in genetic material such as mRNAs and miRNAs). These platelet-derived products induce several phenotypic changes in cancer cells which confer high metastatic capacity. A central event involves an aberrant expression of COX-2 which influences cell-cycle progression and contribute to the acquisition of a cell migratory phenotype through the induction of epithelial mesenchymal transition genes and down-regulation of E-cadherin expression. The identification of novel molecular determinants involved in the cross-talk between platelets and cancer cells has led to identify novel targets for anti-cancer drug development.
KW  - colon cancer cells
KW  - cyclooxygenase 1 (COX-1)
KW  - cyclooxygenase 2 (COX-2)
KW  - epithelial mesenchymal transition
KW  - metastasis
KW  - platelets
Y1  - 2015
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/40338
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-403383
VL  - 43
IS  - 4
SP  - 707
EP  - 714
PB  - Portland Press
CY  - London
ER  -