TY  - JOUR
A1  - Anadol, Evrim
A1  - Beckebaum, Susanne
A1  - Radecke, Klaus
A1  - Paul, Andreas
A1  - Zoufaly, Alexander
A1  - Bickel, Markus
A1  - Hitzenbichler, Florian
A1  - Ganten, Tom M.
A1  - Kittner, Jens Martin
A1  - Stoll, Matthias
A1  - Berg, C.
A1  - Manekeller, Steffen
A1  - Kalff, Jörg C.
A1  - Sauerbruch, Tilman
A1  - Rockstroh, Jürgen
A1  - Spengler, Ulrich
T1  - Orthotopic liver transplantation in human-immunodeficiency-virus-positive patients in Germany
T2  - AIDS research and treatment
N2  - Objectives: This summary evaluates the outcomes of orthotopic liver transplantation (OLT) of HIV-positive patients in Germany. 

Methods: Retrospective chart analysis of HIV-positive patients, who had been liver-transplanted in Germany between July 1997 and July 2011. 

Results: 38 transplantations were performed in 32 patients at 9 German transplant centres. The reasons for OLT were end-stage liver disease (ESLD) and/or liver failure due to hepatitis C (HCV) (n = 19), hepatitis B (HBV) (n = 10), multiple viral infections of the liver (n = 2) and Budd-Chiari-Syndrome. In July 2011 19/32 (60%) of the transplanted patients were still alive with a median survival of 61 months (IQR (interquartile range): 41-86 months). 6 patients had died in the early post-transplantation period from septicaemia (n = 4), primary graft dysfunction (n = 1), and intrathoracal hemorrhage (n = 1). Later on 7 patients had died from septicaemia (n = 2), delayed graft failure (n = 2), recurrent HCC (n = 2), and renal failure (n = 1). Recurrent HBV infection was efficiently prevented in 11/12 patients; HCV reinfection occurred in all patients and contributed considerably to the overall mortality. 

Conclusions: Overall OLT is a feasible approach in HIV-infected patients with acceptable survival rates in Germany. Reinfection with HCV still remains a major clinical challenge in HIV/HCV coinfection after OLT.
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/26769
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-267694
SN  - 2090-1259
SN  - 2090-1240
N1  - Copyright © 2012 E. Anadol et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 2012
IS  - Article ID 197501
PB  - Hindawi
CY  - New York, NY
ER  -