TY  - JOUR
A1  - Niland, Stephan
A1  - Eble, Johannes A.
T1  - Integrin-mediated cell-matrix interaction in physiological and pathological blood vessel formation
T2  - Journal of oncology
N2  - Physiological as well as pathological blood vessel formation are fundamentally dependent on cell-matrix interaction. Integrins, a family of major cell adhesion receptors, play a pivotal role in development, maintenance, and remodeling of the vasculature. Cell migration, invasion, and remodeling of the extracellular matrix (ECM) are integrin-regulated processes, and the expression of certain integrins also correlates with tumor progression. Recent advances in the understanding of how integrins are involved in the regulation of blood vessel formation and remodeling during tumor progression are highlighted. The increasing knowledge of integrin function at the molecular level, together with the growing repertoire of integrin inhibitors which allow their selective pharmacological manipulation, makes integrins suited as potential diagnostic markers and therapeutic targets.
Y1  - 2011
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/24263
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-242635
SN  - 1687-8469
SN  - 1687-8450
VL  - 2012
IS  - Article ID 125278
PB  - Hindawi Publ. Corp.
CY  - New York, NY
ER  -