TY  - JOUR
A1  - Teschke, Rolf
A1  - Danan, Gaby
T1  - Idiosyncratic drug-induced liver injury (DILI) and herb-induced liver injury (HILI): diagnostic algorithm based on the quantitative Roussel Uclaf Causality Assessment Method (RUCAM)
T2  - Diagnostics
N2  - Causality assessment in liver injury induced by drugs and herbs remains a debated issue, requiring innovation and thorough understanding based on detailed information. Artificial intelligence (AI) principles recommend the use of algorithms for solving complex processes and are included in the diagnostic algorithm of Roussel Uclaf Causality Assessment Method (RUCAM) to help assess causality in suspected cases of idiosyncratic drug-induced liver injury (DILI) and herb-induced liver injury (HILI). From 1993 until the middle of 2020, a total of 95,865 DILI and HILI cases were assessed by RUCAM, outperforming by case numbers any other causality assessment method. The success of RUCAM can be traced back to its quantitative features with specific data elements that are individually scored leading to a final causality grading. RUCAM is objective, user friendly, transparent, and liver injury specific, with an updated version that should be used in future DILI and HILI cases. Support of RUCAM was also provided by scientists from China, not affiliated to any network, in the results of a scientometric evaluation of the global knowledge base of DILI. They highlighted the original RUCAM of 1993 and their authors as a publication quoted the greatest number of times and ranked first in the category of the top 10 references related to DILI. In conclusion, for stakeholders involved in DILI and HILI, RUCAM seems to be an effective diagnostic algorithm in line with AI principles.
KW  - artificial intelligence (AI)
KW  - CAM
KW  - diagnostic algorithm
KW  - idiosyncratic drug-induced liver injury (DILI)
KW  - herb-induced liver injury (HILI)
KW  - quantitative RUCAM
KW  - Roussel Uclaf Causality Assess- ment Method (RUCAM)
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62144
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-621447
SN  - 2075-4418
VL  - 11
IS  - 3, art. 458
SP  - 1
EP  - 14
PB  - MDPI
CY  - Basel
ER  -