TY  - JOUR
A1  - Lamparter, Julia
A1  - Schmidtmann, Irene
A1  - Schuster, Alexander K.
A1  - Siouli, Angeliki
A1  - Wasielica-Poślednik, Joanna Katarzyna
A1  - Mirshahi, Alireza
A1  - Höhn, René
A1  - Unterrainer, Josef
A1  - Wild, Philipp
A1  - Binder, Harald
A1  - Lackner, Karl Johannes
A1  - Beutel, Manfred
A1  - Münzel, Thomas
A1  - Pfeiffer, Norbert
A1  - Hoffmann, Esther Maria
T1  - Association of ocular, cardiovascular, morphometric and lifestyle parameters with retinal nerve fibre layer thickness
T2  - PLoS One
N2  - Background: Glaucoma is a neurodegenerative disease, leading to thinning of the retinal nerve fibre layer (RNFL). The exact influence of ocular, cardiovascular, morphometric, lifestyle and cognitive factors on RNFL thickness (RNFLT) is unknown and was analysed in a subgroup of the Gutenberg Health Study (GHS).
Methods: Global peripapillary RNFLT was measured in 3224 eyes of 1973 subjects (49% female) using spectral-domain optical coherence tomography (SD-OCT). The association of age, sex, ocular, cardiovascular, morphometric, lifestyle and cognitive factors on RNFLT was analysed using Pearson correlation coefficient and fitting a linear mixed model.
Results: In the univariable analysis highest correlations were found for axial length (r = -0.27), spherical equivalent (r = 0.24), and glaucoma (r = -0.15) (p<0.0001, respectively). Other significant correlations with RNFLT were found for age, sex, intraocular pressure, systemic hypertension and systolic blood pressure, previous eye surgery, cholesterol, homocysteine, history of coronary artery disease, history of myocardial infarction, apnoea, diabetes and alcohol intake, p<0.05, respectively. Body length, body weight, BMI, diastolic blood pressure, blood glucose, HbA1c, history of apoplexy, cognitive function, peripheral artery disease, tinnitus, migraine, nicotine intake, central corneal thickness, and pseudophakia were not significantly correlated with RNFLT. The regression model revealed a significant relationship between RNFLT and age in decades (p<0.02), spherical equivalent (p<0.0001), axial length (p<0.0001), glaucoma (p<0.0001), tinnitus (p = 0.04), apnoea (p = 0.047), homocysteine (p = 0.05) and alcohol intake >10g/d for women and >20g/d for men (p = 0.02). Glaucoma, apnoea, higher homocysteine, higher alcohol intake and higher axial length as well as age were related to decreased RNFLT while higher spherical equivalent or history for tinnitus were related to thicker RNFL.
Conclusion: RNFLT is related to age, ocular parameters and lifestyle factors. Considering these parameters in normative databases could improve the evaluation of peripapillary RNFLT. It is necessary to evaluate if a reduction of alcohol intake as well as the therapy of apnea or high homocysteine levels could positively influence RNFLT.
KW  - Alcohol consumption
KW  - Glaucoma
KW  - Nerve fibers
KW  - Eyes
KW  - Blood pressure
KW  - Morphometry
KW  - Tinnitus
KW  - Tomography
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/46556
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-465569
SN  - 1932-6203
N1  - Copyright: © 2018 Lamparter et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 13
IS  - (5): e0197682
SP  - 1
EP  - 11
PB  - PLoS
CY  - Lawrence, Kan.
ER  -