TY  - JOUR
A1  - Piffkó, András
A1  - Uhl, Christian
A1  - Vajkoczy, Peter
A1  - Czabanka, Marcus Alexander
A1  - Broggini, Thomas
T1  - EphrinB2-EphB4 signaling in neurooncological disease
T2  - International journal of molecular sciences
N2  - EphrinB2–EphB4 signaling is critical during embryogenesis for cardiovascular formation and neuronal guidance. Intriguingly, critical expression patterns have been discovered in cancer pathologies over the last two decades. Multiple connections to tumor migration, growth, angiogenesis, apoptosis, and metastasis have been identified in vitro and in vivo. However, the molecular signaling pathways are manifold and signaling of the EphB4 receptor or the ephrinB2 ligand is cancer type specific. Here we explore the impact of these signaling pathways in neurooncological disease, including glioma, brain metastasis, and spinal bone metastasis. We identify potential downstream pathways that mediate cancer suppression or progression and seek to understand it´s role in antiangiogenic therapy resistance in glioma. Despite the Janus-faced functions of ephrinB2–EphB4 signaling in cancer Eph signaling remains a promising clinical target.
KW  - EphB4
KW  - ephrinB2
KW  - metastasis
KW  - glioblastoma
KW  - glioma
KW  - bone
KW  - brain metastasis
KW  - spinal metastasis
KW  - neurooncology
KW  - bone metastasis
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/81025
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-810258
SN  - 1422-0067
N1  - This research was funded by the German research foundation DFG GEPRIS: 267716524 and the FOR2325 DFG Forschergruppe.
VL  - 23
IS  - 3, art. 1679
SP  - 1
EP  - 17
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  -