TY  - JOUR
A1  - Lenz, Maximilian
A1  - Galanis, Christos
A1  - Müller-Dahlhaus, Florian
A1  - Opitz, Alexander
A1  - Wierenga, Corette
A1  - Szabó, Gábor
A1  - Ziemann, Ulf
A1  - Deller, Thomas
A1  - Funke, Klaus
A1  - Vlachos, Andreas
T1  - Repetitive magnetic stimulation induces plasticity of inhibitory synapses
T2  - Nature Communications
N2  - Repetitive transcranial magnetic stimulation (rTMS) is used as a therapeutic tool in neurology and psychiatry. While repetitive magnetic stimulation (rMS) has been shown to induce plasticity of excitatory synapses, it is unclear whether rMS can also modify structural and functional properties of inhibitory inputs. Here we employed 10-Hz rMS of entorhinohippocampal slice cultures to study plasticity of inhibitory neurotransmission on CA1 pyramidal neurons. Our experiments reveal a rMS-induced reduction in GABAergic synaptic strength (2–4 h after stimulation), which is Ca2+-dependent and accompanied by the remodelling of postsynaptic gephyrin scaffolds. Furthermore, we present evidence that 10-Hz rMS predominantly acts on dendritic, but not somatic inhibition. Consistent with this finding, a reduction in clustered gephyrin is detected in CA1 stratum radiatum of rTMS-treated anaesthetized mice. These results disclose that rTMS induces coordinated Ca2+-dependent structural and functional changes of specific inhibitory postsynapses on principal neurons.
KW  - Excitability
KW  - Synaptic plasticity
KW  - Therapeutics
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50641
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-506414
SN  - 2041-1723
N1  - This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
VL  - 7
IS  - Art. 10020
SP  - 1
EP  - 13
PB  - Nature Publishing Group UK
CY  - [London]
ER  -