TY  - JOUR
A1  - Dubinski, Daniel
A1  - Won, Sae-Yeon
A1  - Behmanesh, Bedjan
A1  - Dosch, Maximilian
A1  - Schneider, Viktoria
A1  - Baumgarten, Peter
A1  - Bernstock, Joshua D.
A1  - Voß, Martin
A1  - Schuß, Patrick
A1  - Konczalla, Jürgen
A1  - Czabanka, Marcus Alexander
A1  - Freiman, Thomas Michael
A1  - Geßler, Florian
T1  - Therapeutic anticoagulation impacts MR morphologic recurrence patterns in glioblastoma - a matched-pair analysis
T2  - Journal of Clinical Medicine
N2  - Background: Glioblastoma (GBM) patients are at particularly high risk for thrombotic complications. In the event of a postoperative pulmonary embolism, therapeutic anticoagulation (tAC) is indispensable. The impact of therapeutic anticoagulation on recurrence pattern in GBM is currently unknown. Methods: We conducted a matched-pair cohort analysis of 57 GBM patients with or without tAC that were matched for age, sex, gross total resection and MGMT methylation status in a ratio of 1:2. Patients’ characteristics and clinical course were evaluated using medical charts. MRI characteristics were evaluated by two independent authors blinded to the AC status. Results: The morphologic MRI appearance in first GBM recurrence showed a significantly higher presence of multifocal, midline crossing and sharp demarcated GBM recurrence patterns in patients with therapeutic tAC compared to the matched control group. Although statistically non-significant, the therapeutic tAC cohort showed increased survival. Conclusion: Therapeutic anticoagulation induced significant morphologic changes in GBM recurrences. The underlying pathophysiology is discussed in this article but remains to be further elucidated.
KW  - pulmonary embolism
KW  - therapeutic anticoagulation
KW  - recurrence pattern
KW  - glioblastoma survival
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/80033
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-800339
SN  - 2077-0383
VL  - 11
IS  - 2, art. 422
SP  - 1
EP  - 8
PB  - MDPI
CY  - Basel
ER  -