TY  - JOUR
A1  - Kristof, Katalin
A1  - Büttner, Benedikt
A1  - Grimm, Anna
A1  - Mewes, Caspar
A1  - Schmack, Bastian
A1  - Popov, Aron-Frederik
A1  - Ghadimi, Michael
A1  - Beißbarth, Tim
A1  - Hinz, José-Maria
A1  - Bergmann, Ingo
A1  - Mansur, Ashham
T1  - Anaemia requiring red blood cell transfusion is associated with unfavourable 90-day survival in surgical patients with sepsis
T2  - BMC Research Notes
N2  - Objective: The mortality associated with sepsis remains unacceptably high, despite modern high-quality intensive care. Based on the results from previous studies, anaemia and its management in patients with sepsis appear to impact outcomes; however, the transfusion policy is still being debated, and the ideal approach may be extremely specific to the individual. This study aimed to investigate the long-term impact of anaemia requiring red blood cell (RBC) transfusion on mortality and disease severity in patients with sepsis. We studied a general surgical intensive care unit (ICU) population, excluding cardiac surgery patients. 435 patients were enrolled in this observational study between 2012 and 2016.
Results: Patients who received RBC transfusion between 28 days before and 28 days after the development of sepsis (n = 302) exhibited a significantly higher 90-day mortality rate (34.1% vs 19.6%; P = 0.004, Kaplan–Meier analysis). This association remained significant after adjusting for confounders in the multivariate Cox regression analysis (hazard ratio 1.68; 95% confidence interval 1.03–2.73; P = 0.035). Patients who received transfusions also showed significantly higher morbidity scores, such as SOFA scores, and ICU lengths of stay compared to patients without transfusions (n = 133). Our results indicate that anaemia and RBC transfusion are associated with unfavourable outcomes in patients with sepsis.
KW  - Sepsis
KW  - Red blood cell transfusion
KW  - Surgical ICU
KW  - Mortality
KW  - Organ dysfunction
KW  - Survival
KW  - Organ support
KW  - Morbidity
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50051
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-500515
SN  - 1756-0500
N1  - Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
VL  - 11
IS  - 1, Art. 879
SP  - 1
EP  - 7
PB  - Biomed Central
CY  - London
ER  -