TY  - JOUR
A1  - Sepčić, Kristina
A1  - Kauferstein, Silke
A1  - Mebs, Dietrich
A1  - Turk, Tom
T1  - Biological activities of aqueous and organic extracts from tropical marine sponges
T2  - Marine drugs
N2  - We report on screening tests of 66 extracts obtained from 35 marine sponge species from the Caribbean Sea (Curaçao) and from eight species from the Great Barrier Reef (Lizard Island). Extracts were prepared in aqueous and organic solvents and were tested for hemolytic, hemagglutinating, antibacterial and anti-acetylcholinesterase (AChE) activities, as well as their ability to inhibit or activate cell protein phosphatase 1 (PP1). The most interesting activities were obtained from extracts of Ircinia felix, Pandaros acanthifolium, Topsentia ophiraphidites, Verongula rigida and Neofibularia nolitangere. Aqueous and organic extracts of I. felix and V. rigida showed strong antibacterial activity. Topsentia aqueous and some organic extracts were strongly hemolytic, as were all organic extracts from I. felix. The strongest hemolytic activity was observed in aqueous extracts from P. acanthifolium. Organic extracts of N. nolitangere and I. felix inhibited PP1. The aqueous extract from Myrmekioderma styx possessed the strongest hemagglutinating activity, whilst AChE inhibiting activity was found only in a few sponges and was generally weak, except in the methanolic extract of T. ophiraphidites.
KW  - tropical marine sponges
KW  - hemolysis
KW  - hemagglutination
KW  - antibacterial activity
KW  - acetylcholinesterase (AChE) inhibition
KW  - protein phosphatase 1 (PP1) inhibition/activation
Y1  - 2010
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/25310
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-253105
SN  - 1660-3397
VL  - 8.2010
IS  - 5
SP  - 1550
EP  - 1566
PB  - Molecular Diversity Preservation International (MDPI)
CY  - Basel
ER  -