TY  - JOUR
A1  - Müller-Dahlhaus, Florian
A1  - Vlachos, Andreas
T1  - Unraveling the cellular and molecular mechanisms of repetitive magnetic stimulation
T2  - Frontiers in molecular neuroscience
N2  - Despite numerous clinical studies, which have investigated the therapeutic potential of repetitive transcranial magnetic stimulation (rTMS) in various brain diseases, our knowledge of the cellular and molecular mechanisms underlying rTMS-based therapies remains limited. Thus, a deeper understanding of rTMS-induced neural plasticity is required to optimize current treatment protocols. Studies in small animals or appropriate in vitro preparations (including models of brain diseases) provide highly useful experimental approaches in this context. State-of-the-art electrophysiological and live-cell imaging techniques that are well established in basic neuroscience can help answering some of the major questions in the field, such as (i) which neural structures are activated during TMS, (ii) how does rTMS induce Hebbian plasticity, and (iii) are other forms of plasticity (e.g., metaplasticity, structural plasticity) induced by rTMS? We argue that data gained from these studies will support the development of more effective and specific applications of rTMS in clinical practice.
KW  - non-invasive brain stimulation
KW  - neurological diseases
KW  - neuropsychiatric disorders
KW  - Hebbian plasticity
KW  - metaplasticity
KW  - structural plasticity
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/32811
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-328112
SN  - 1662-5099
N1  - Copyright © 2013 Müller-Dahlhaus and Vlachos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
VL  - 6
IS  - Article 50
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -