TY  - JOUR
A1  - Kleemann, Johannes
A1  - Hrgovic, Igor
A1  - Kleimann, Pia
A1  - Ter‐Nedden, Jan Wilhelm
A1  - Glaser, Melanie
A1  - Steinhorst, Katja
A1  - Härle, Katja
A1  - Müller, Jutta
A1  - Kaufmann, Roland
A1  - Kippenberger, Stefan
A1  - Meissner, Markus
T1  - G protein‐coupled receptor 40 expression in human melanoma – correlation with tumour thickness, AJCC stage and survival
T2  - Journal of the European Academy of Dermatology and Venereology
N2  - Background In melanoma, preclinical data suggest a possible role of polyunsaturated fatty acids inhibiting cell growth. A new target molecule for free fatty acids, the G protein-coupled receptor GPR40, was identified in melanoma cells.
Objectives The aim of this study was to investigate GPR40 expression in human melanocytic tissues and to evaluate its potential as a prognostic marker.
Methods and Results A total of 114 tissue sections of naevi, primary melanoma and melanoma metastasis were immunohistochemically stained with anti-GPR40. The staining was evaluated, using the immunoreactivity scoring system. Compared to naevi, primary melanoma and melanoma metastasis showed significantly higher levels of GPR40 (P < 0.05). In primary melanoma, GPR40 expression positively correlated with tumour thickness (P = 0.044) and AJCC level (P = 0.017) and in melanoma metastasis with AJCC level (P = 0.035). Primary melanoma patients with high levels of GPR40 had a significantly poorer overall survival (P = 0.004) and shorter disease-free survival (0.040).
Conclusion The present study identified GPR40 as a novel target molecule in melanoma. First evidence for a potential role of the receptor in tumour progression and metastases was found, and it could be demonstrated that GPR40 expression is negatively correlated with patient’s survival.
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57204
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-572044
SN  - 1468-3083
SN  - 0926-9959
VL  - 34
IS  - 2
SP  - 285
EP  - 292
PB  - Wiley-Blackwell
CY  - Oxford [u.a.]
ER  -