TY  - JOUR
A1  - Köbe, Theresa
A1  - Witte, A. Veronica
A1  - Schnelle, Ariane
A1  - Tesky, Valentina
A1  - Pantel, Johannes
A1  - Schuchardt, Jan-Philipp
A1  - Hahn, Andreas
A1  - Bohlken, Jens
A1  - Grittner, Ulrike
A1  - Flöel, Agnes
T1  - Impact of resveratrol on glucose control, hippocampal structure and connectivity, and memory performance in patients with mild cognitive impairment
T2  - Frontiers in neuroscience
N2  - In healthy older adults, resveratrol supplementation has been shown to improve long-term glucose control, resting-state functional connectivity (RSFC) of the hippocampus, and memory function. Here, we aimed to investigate if these beneficial effects extend to individuals at high-risk for dementia, i.e., patients with mild cognitive impairment (MCI). In a randomized, double-blind interventional study, 40 well-characterized patients with MCI (21 females; 50–80 years) completed 26 weeks of resveratrol (200 mg/d; n = 18) or placebo (1,015 mg/d olive oil; n = 22) intake. Serum levels of glucose, glycated hemoglobin A1c and insulin were determined before and after intervention. Moreover, cerebral magnetic resonance imaging (MRI) (3T) (n = 14 vs. 16) was conducted to analyze hippocampus volume, microstructure and RSFC, and neuropsychological testing was conducted to assess learning and memory (primary endpoint) at both time points. In comparison to the control group, resveratrol supplementation resulted in lower glycated hemoglobin A1c concentration with a moderate effect size (ANOVARM p = 0.059, Cohen's d = 0.66), higher RSFC between right anterior hippocampus and right angular cortex (p < 0.001), and led to a moderate preservation of left anterior hippocampus volume (ANOVARM p = 0.061, Cohen's d = 0.68). No significant differences in memory performance emerged between groups. This proof-of-concept study indicates for the first-time that resveratrol intake may reduce glycated hemoglobin A1c, preserves hippocampus volume, and improves hippocampus RSFC in at-risk patients for dementia. Larger trials with longer intervention time should now determine if these benefits can be validated and extended to cognitive function.
KW  - hippocampus
KW  - memory performance
KW  - MCI
KW  - resting-state functional connectivity
KW  - resveratrol
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/43176
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-431768
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339301
SN  - 1662-453X
SN  - 1662-4548
N1  - Copyright © 2017 Köbe, Witte, Schnelle, Tesky, Pantel, Schuchardt, Hahn, Bohlken, Grittner and Flöel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
VL  - 11
IS  - Art. 105
SP  - 1
EP  - 11
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -