TY  - JOUR
A1  - Ito, Junji
A1  - Maldonado, Pedro
A1  - Singer, Wolf
A1  - Grün, Sonja
T1  - Saccade-related modulations of neuronal excitability support synchrony of visually elicited spikes
T2  - Cerebral cortex
N2  - During natural vision, primates perform frequent saccadic eye movements, allowing only a narrow time window for processing the visual information at each location. Individual neurons may contribute only with a few spikes to the visual processing during each fixation, suggesting precise spike timing as a relevant mechanism for information processing. We recently found in V1 of monkeys freely viewing natural images, that fixation-related spike synchronization occurs at the early phase of the rate response after fixation-onset, suggesting a specific role of the first response spikes in V1. Here, we show that there are strong local field potential (LFP) modulations locked to the onset of saccades, which continue into the successive fixation periods. Visually induced spikes, in particular the first spikes after the onset of a fixation, are locked to a specific epoch of the LFP modulation. We suggest that the modulation of neural excitability, which is reflected by the saccade-related LFP changes, serves as a corollary signal enabling precise timing of spikes in V1 and thereby providing a mechanism for spike synchronization.
KW  - free viewing
KW  - local field potential
KW  - phase locking
KW  - primary visual cortex
KW  - spike synchrony
Y1  - 2011
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/27265
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-272653
SN  - 1047-3211
SN  - 1460-2199
N1  - © The Authors 2011. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 21
IS  - 11
SP  - 2482
EP  - 2497
PB  - Oxford Univ. Press
CY  - Oxford
ER  -