TY  - JOUR
A1  - Schrecker, Christopher
A1  - Waidmann, Oliver
A1  - Youzouri, Hanan el
A1  - Trojan, Jörg
A1  - Schnitzbauer, Andreas
A1  - Bechstein, Wolf Otto
A1  - Zeuzem, Stefan
A1  - Koch, Christine
T1  - Low platelet count predicts reduced survival in potentially resectable hepatocellular carcinoma
T2  - Current oncology
N2  - The prognostic role of platelet count in hepatocellular carcinoma (HCC) remains unclear, and in fact both thrombocytopenia and thrombocytosis are reported as predictors of unfavourable outcomes. This study aimed to clarify the prognostic value of preoperative platelet count in potentially resectable HCC. We retrospectively reviewed 128 patients who underwent hepatic resection for HCC at a tertiary academic centre (2007–2019). Patient data were modelled by regression analysis, and platelet count was treated as a continuous variable. 89 patients had BCLC 0/A tumours and 39 had BCLC B tumours. Platelet count was higher in patients with larger tumours and lower in patients with higher MELD scores, advanced fibrosis, and portal hypertension (p < 0.001 for all listed variables). After adjusting for BCLC stage and tumour diameter, low platelet count associated with reduced overall survival (hazard ratio 1.25 per 50/nL decrease in platelet count, 95% confidence interval (CI) 1.02–1.53, p = 0.034) and increased perioperative mortality (odds ratio 1.96 per 50/nL decrease in platelet count, 95% CI 1.19–3.53, p = 0.014). Overall, low platelet count correlates with increased liver disease severity, inferior survival, and excess perioperative mortality in resectable HCC. These insights might be applied in clinical practice to better select patients for resection.
KW  - cirrhosis
KW  - hepatocellular carcinoma
KW  - overall survival
KW  - perioperative mortality
KW  - platelet count
KW  - portal hypertension
KW  - thrombocytopenia
KW  - thrombocytosis
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/81806
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-818069
SN  - 1718-7729
VL  - 29
IS  - 3
SP  - 1475
EP  - 1487
PB  - Multimed
CY  - Toronto, Ontario
ER  -