TY  - JOUR
A1  - Miladinovic, Milica
A1  - Wittekindt, Boris
A1  - Fischer, Sebastian
A1  - Gradhand, Elise
A1  - Kunzmann, Steffen
A1  - Zimmermann, Stefanie-Yvonne
A1  - Bakhtiar, Shahrzad
A1  - Klingebiel, Thomas
A1  - Schlösser, Rolf
A1  - Lehrnbecher, Thomas
T1  - Case report : symptomatic chronic granulomatous disease in the newborn
T2  - Frontiers in immunology
N2  - Chronic granulomatous disease (CGD) is a primary immunodeficiency, which is diagnosed in most patients between one and three years of age. Here we report on a boy who presented at birth with extensive skin lesions and lymphadenopathy which were caused by CGD. An analysis of the literature revealed 24 patients with CGD who became symptomatic during the first six weeks of life. Although pulmonary complications and skin lesions due to infection were the leading symptoms, clinical features were extremely heterogenous. As follow-up was not well specified in most patients, the long-term prognosis of children with very early onset of CGD remains unknown.
KW  - chronic granulomatous disease
KW  - neonate
KW  - early onset
KW  - symptoms
KW  - outcome
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/61130
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-611303
SN  - 1664-3224
VL  - 12
IS  - art. 663883
SP  - 1
EP  - 9
PB  - Frontiers Media
CY  - Lausanne
ER  -