TY  - JOUR
A1  - Endres, Elisa
A1  - Drongelen, Stefan van
A1  - Meurer, Andrea
A1  - Zaucke, Frank
A1  - Stief, Felix
T1  - Effect of total joint replacement in hip osteoarthritis on serum COMP and its correlation with mechanical-functional parameters of gait analysis
T2  - Osteoarthritis and cartilage open
N2  - Objective: To study the effect of total hip replacement (THR) on serum cartilage oligomeric matrix protein concentration (sCOMP) and its correlation with joint loading during gait in patients with unilateral hip osteoarthritis.
Design: In this prospective multimodal (clinical, biomechanical, biochemical) study blood samples from 15 patients were taken before and up to three times after THR (7 days, 3 months and 1 year), each after a resting period of at least 30 min, for analysis of sCOMP. Gait analysis was performed before and 1 year after THR to determine hip and knee joint moments.
Results: Seven days after THR, sCOMP decreased significantly compared to the preoperative measurement (p < 0.001). Three months and 1 year postoperatively, sCOMP reverted to concentrations in the range of the preoperative value. One year postoperatively, a linear correlation between sCOMP and the maximum hip flexion moment was indicated in the first half of the stance phase on the unaffected side (r = −0.736, p = 0.024). No further correlations could be determined.
Conclusions: Surprisingly, the removal of a joint affected by osteoarthritis did not have a sustained effect on sCOMP. Both before and after THR there was no scientifically substantiated correlation between sCOMP and joint moments from gait analysis. Consequently, the examination of sCOMP is not useful to detect altered joint loads that may influence degenerative changes of adjacent joints after THR.
The registration number in the German Registry of Clinical Trials is DRKS00015053.
KW  - COMP
KW  - Serum biomarker
KW  - Total hip arthroplasty
KW  - Osteoarthritis
KW  - Gait analysis
KW  - Joint loading
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/55278
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-552787
SN  - 2665-9131
N1  - © 2020 Osteoarthritis Research Society International (OARSI). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license
VL  - 2
IS  - 1, art. 100034
SP  - 1
EP  - 7
PB  - Elsevier
CY  - Amsterdam
ER  -