TY  - JOUR
A1  - Pesic, Deniel
A1  - Srejovic, Ivan
A1  - Stefanovic, Djordje
A1  - Djordjevic, Dusica
A1  - Cubrilo, Dejan
A1  - Zivkovic, Vladimir
T1  - Ten marathons in ten days: effects on biochemical parameters and redox balance – case report
T1  - Deset maratona za deset dana: uticaj na biohemiske
parametre i redoks ravnotežu – prikaz slučaja
T2  - Serbian journal of experimental and clinical research
N2  - Production of free radicals and oxidative damage during physical activity is a topic that is intensively studied and paid a lot of attention, first of all in professional sports. Marathon is categorized as extremely demanding sports discipline, as it induces high energy consumption and also requires special mental self-control. We presented cases of two athletes of different age, who have been on dissimilar level of sports readiness, and also had various approach to physical activity and exercise. During 10 days they ran out 10 marathons, partly on a flat terrain, and partly on hilly, which produced different level of effort in conquering the terrain. Also, both athletes had complex supplementation scheme in order to prevent electrolyte imbalance and excessive production of free radicals. Blood samples were taken in the morning and immediately after the end of the marathon. Measured oxidative stress biomarkers changed without a noticeable pattern, but these changes did not vary greatly among themselves. Catalase activity in both marathon runners was higher after marathon almost after every race for 10 days. On the other hand, amount of reduced glutathione was lower after marathon in both athletes in the same manner. Based on the obtained results we can conclude that adequate supplementation could have crucial role in prevention of oxidative damage.
N2  - Stvaranje slobodnih radikala i oksidaciono oštećenje je tema kojoj se posvećuje dosta pažnje i koja se intenzivno istražuje, pre svega kod profesionalnih sportista. Maraton se svrstava u izuzetno zahtevne sportske discipline koja podrazumeva veliku energetsku potrošnju i specifičnu mental-nu samokontrolu. Prikazali smo slučaj dvojice maratonaca različite starosne dobi, različite fizičke spremnosti i sa različitim prisupom fizičkoj aktivnosti i vežbanju. Tokom 10 dana istrčali su 10 maratona, delom na ravnom, a delom na brdovitom terenu, što je uzrokovalo različito opterećenje tokom savladavanja pojedinih deonica. Takođe, trkači su imali kompleksnu shemu suplementacije u cilju prevencije elektrolitnog disbalansa i prekomerne produkcije slobodnih radikala. Uzorci krvi su uzimani ujutru i odmah nakon završetka maratona. Promne vrednosti merenih biomarkera oksidacionog stresa nisu imale bilo kakav obrazac, ali ove promene nisu značajno varirale između maratonaca. Aktivnost katalaze kod oba maratonca je bila znatno viša nakon maratona gotovo tokom svih 10 dana. Sa druge strane, količina redukovanog glutationa je bila niža nakon maraton kod oba trkača. Na osnovu dobijenih rezultata može da se zaključi da adekvatna suplementacija može da ima presudnu ulogu u prevenciji oksidacionog oštećenja.
KW  - marathon
KW  - physical activity
KW  - oxidative stress
KW  - reactive oxygen species
KW  - supplementation
KW  - maraton
KW  - fizička aktivnost;
KW  - oksidacioni stres
KW  - reaktivne vrste kiseonika
KW  - suplementacija
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/56066
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-560660
SN  - 2335-075X
SN  - 1820-8665
VL  - 20
IS  - 4
SP  - 361
EP  - 365
PB  - De Gruyter Open
CY  - Warsaw
ER  -