TY  - JOUR
A1  - Schulze, Johannes B.
A1  - Melzer, Lena
A1  - Smith, Lisa
A1  - Teschke, Rolf
T1  - Green tea and its extracts in cancer prevention and treatment
T2  - Beverages
N2  - Green tea (GT) and green tea extracts (GTE) have been postulated to decrease cancer incidence. In vitro results indicate a possible effect; however, epidemiological data do not support cancer chemoprevention. We have performed a PubMED literature search for green tea consumption and the correlation to the common tumor types lung, colorectal, breast, prostate, esophageal and gastric cancer, with cohorts from both Western and Asian countries. We additionally included selected mechanistical studies for a possible mode of action. The comparability between studies was limited due to major differences in study outlines; a meta analysis was thus not possible and studies were evaluated individually. Only for breast cancer could a possible small protective effect be seen in Asian and Western cohorts, whereas for esophagus and stomach cancer, green tea increased the cancer incidence, possibly due to heat stress. No effect was found for colonic/colorectal and prostatic cancer in any country, for lung cancer Chinese studies found a protective effect, but not studies from outside China. Epidemiological studies thus do not support a cancer protective effect. GT as an indicator of as yet undefined parameters in lifestyle, environment and/or ethnicity may explain some of the observed differences between China and other countries.
KW  - chemoprevention
KW  - epidemiology
KW  - breast cancer
KW  - colorectal cancer
KW  - esophageal cancer
KW  - gastric cancer
KW  - lung cancer
KW  - prostatic cancer
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/44235
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-442353
SN  - 2306-5710
N1  - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
VL  - 3
IS  - Heft 1, Nr. 17
SP  - 1
PB  - MDPI
CY  - Basel
ER  -