TY  - JOUR
A1  - Hintermann, Edith
A1  - Christen, Urs
T1  - The many roles of cell adhesion molecules in hepatic fibrosis
T2  - Cells
N2  - Fibrogenesis is a progressive scarring event resulting from disrupted regular wound healing due to repeated tissue injury and can end in organ failure, like in liver cirrhosis. The protagonists in this process, either liver-resident cells or patrolling leukocytes attracted to the site of tissue damage, interact with each other by soluble factors but also by direct cell-cell contact mediated by cell adhesion molecules. Since cell adhesion molecules also support binding to the extracellular matrix, they represent excellent biosensors, which allow cells to modulate their behavior based on changes in the surrounding microenvironment. In this review, we focus on selectins, cadherins, integrins and members of the immunoglobulin superfamily of adhesion molecules as well as some non-classical cell adhesion molecules in the context of hepatic fibrosis. We describe their liver-specific contributions to leukocyte recruitment, cell differentiation and survival, matrix remodeling or angiogenesis and touch on their suitability as targets in antifibrotic therapies.
KW  - cell adhesion
KW  - liver fibrosis
KW  - selectin
KW  - integrin
KW  - cadherin
KW  - immunoglobulin superfamily
KW  - junctional adhesion molecule
KW  - non-classical adhesion molecule
KW  - antifibrotic therapy
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/52624
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-526244
SN  - 2073-4409
N1  - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
VL  - 8
IS  - 12, Art. 1503
SP  - 1
EP  - 27
PB  - MDPI
CY  - Basel
ER  -