TY  - JOUR
A1  - Syed, Shahzad Nawaz
A1  - Frank, Ann-Christin
A1  - Raue, Rebecca
A1  - Brüne, Bernhard
T1  - MicroRNA - a tumor trojan horse for tumor-associated macrophages
T2  - Cells
N2  - MicroRNAs (miRs) significantly contribute to the regulation of gene expression, by virtue of their ability to interact with a broad, yet specific set of target genes. MiRs are produced and released by almost every cell type and play an important role in horizontal gene regulation in the tumor microenvironment (TME). In the TME, both tumor and stroma cells cross-communicate via diverse factors including miRs, which are taking central stage as a therapeutic target of anti-tumor therapy. One of the immune escape strategies adopted by tumor cells is to release miRs as a Trojan horse to hijack circulating or tumor-localized monocytes/macrophages to tune them for pro-tumoral functions. On the other hand, macrophage-derived miRs exert anti-tumor functions. The transfer of miRs from host to recipient cells depends on the supramolecular structure and composition of miR carriers, which determine the distinct uptake mechanism by recipient cells. In this review, we provide a recent update on the miR-mediated crosstalk between tumor cells and macrophages and their mode of uptake in the TME.
KW  - microRNA
KW  - tumor-associated macrophages
KW  - macrophage polarization
KW  - CD36
KW  - breast cancer
KW  - inflammation
KW  - miR-375
KW  - exosomes
KW  - LDL
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/51650
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-516501
SN  - 2073-4409
N1  - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
VL  - 8
IS  - 12, Art. 1482
SP  - 1
EP  - 25
PB  - MDPI
CY  - Basel
ER  -