TY  - JOUR
A1  - Uhlhaas, Peter J.
A1  - Singer, Wolf
T1  - High-frequency oscillations and the neurobiology of schizophrenia
T2  - Dialogues in clinical neuroscience
N2  - Neural oscillations at low- and high-frequency ranges are a fundamental feature of large-scale networks. Recent evidence has indicated that schizophrenia is associated with abnormal amplitude and synchrony of oscillatory activity, in particular, at high (beta/gamma) frequencies. These abnormalities are observed during task-related and spontaneous neuronal activity which may be important for understanding the pathophysiology of the syndrome. In this paper, we shall review the current evidence for impaired beta/gamma-band oscillations and their involvement in cognitive functions and certain symptoms of the disorder. In the first part, we will provide an update on neural oscillations during normal brain functions and discuss underlying mechanisms. This will be followed by a review of studies that have examined high-frequency oscillatory activity in schizophrenia and discuss evidence that relates abnormalities of oscillatory activity to disturbed excitatory/inhibitory (E/I) balance. Finally, we shall identify critical issues for future research in this area.
KW  - cognition
KW  - gamma
KW  - neurobiology
KW  - oscillations
KW  - schizophrenia
KW  - synchrony
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/34514
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-345147
N1  - Copyright : © 2013 Institut la Conférence Hippocrate - Servier Research Group. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 15
SP  - 301
EP  - 313
ER  -