TY  - JOUR
A1  - Pham, Tan Phát
A1  - Bergen, Anke S. van
A1  - Kremer, Veerle
A1  - Glaser, Simone F.
A1  - Dimmeler, Stefanie
A1  - Boon, Reinier
T1  - LncRNA AERRIE is required for sulfatase 1 expression, but not for endothelial-to-mesenchymal transition
T2  - International journal of molecular sciences
N2  - Endothelial cells can acquire a mesenchymal phenotype through a process called Endothelial-to-Mesenchymal transition (EndMT). This event is found in embryonic development, but also in pathological conditions. Blood vessels lose their ability to maintain vascular homeostasis and ultimately develop atherosclerosis, pulmonary hypertension, or fibrosis. An increase in inflammatory signals causes an upregulation of EndMT transcription factors, mesenchymal markers, and a decrease in endothelial markers. In our study, we show that the induction of EndMT results in an increase in long non-coding RNA AERRIE expression. JMJD2B, a known EndMT regulator, induces AERRIE and subsequently SULF1. Silencing of AERRIE shows a partial regulation of SULF1 but showed no effect on the endothelial and mesenchymal markers. Additionally, the overexpression of AERRIE results in no significant changes in EndMT markers, suggesting that AERRIE is marginally regulating mesenchymal markers and transcription factors. This study identifies AERRIE as a novel factor in EndMT, but its mechanism of action still needs to be elucidated.
KW  - non-coding RNA
KW  - EndMT
KW  - endothelial cells
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62362
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-623620
SN  - 1422-0067
N1  - This study was supported by the German Centre for Cardiovascular Research (DZHK), theEuropean Research Council (“NOVA”), the Netherlands Organisation for Scientific Research (NWOVidi) and the European Union (Horizon 2020 Grant No. 825670).
VL  - 22
IS  - 15, art. 8088
SP  - 1
EP  - 14
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  -