TY  - JOUR
A1  - Luckowitsch, Marie
A1  - Rudolph, Henriette
A1  - Bochennek, Konrad
A1  - Porto, Luciana
A1  - Lehrnbecher, Thomas
T1  - Central nervous system mold infections in children with hematological malignancies: advances in diagnosis and treatment
T2  - Journal of Fungi
N2  - The incidence of invasive mold disease (IMD) has significantly increased over the last decades, and IMD of the central nervous system (CNS) is a particularly severe form of this infection. Solid data on the incidence of CNS IMD in the pediatric setting are lacking, in which Aspergillus spp. is the most prevalent pathogen, followed by mucorales. CNS IMD is difficult to diagnose, and although imaging tools such as magnetic resonance imaging have considerably improved, these techniques are still unspecific. As microscopy and culture have a low sensitivity, non-culture-based assays such as the detection of fungal antigens (e.g., galactomannan or beta-D-glucan) or the detection of fungal nucleic acids by molecular assays need to be validated in children with suspected CNS IMD. New and potent antifungal compounds helped to improve outcome of CNS IMD, but not all agents are approved for children and a pediatric dosage has not been established. Therefore, studies have to rapidly evaluate dosage, safety and efficacy of antifungal compounds in the pediatric setting. This review will summarize the current knowledge on diagnostic tools and on the management of CNS IMD with a focus on pediatric patients.
KW  - central nervous system
KW  - invasive fungal disease
KW  - child
KW  - mold
KW  - Aspergillus
KW  - mucormycetes
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/61008
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-610088
SN  - 2309-608X
VL  - 7
IS  - 3, art. 168
SP  - 1
EP  - 18
PB  - MDPI
CY  - Basel
ER  -