TY  - JOUR
A1  - Rutz, Jochen
A1  - Maxeiner, Sebastian
A1  - Justin, Saira
A1  - Bachmeier, Beatrice
A1  - Bernd, August
A1  - Kippenberger, Stefan
A1  - Zöller, Nadja Nicole
A1  - Chun, Felix
A1  - Blaheta, Roman A.
T1  - Low dosed curcumin combined with visible light exposure inhibits renal cell carcinoma metastatic behavior in vitro
T2  - Cancers
N2  - Recent documentation shows that a curcumin-induced growth arrest of renal cell carcinoma (RCC) cells can be amplified by visible light. This study was designed to investigate whether this strategy may also contribute to blocking metastatic progression of RCC. Low dosed curcumin (0.2 µg/mL; 0.54 µM) was applied to A498, Caki1, or KTCTL-26 cells for 1 h, followed by exposure to visible light for 5 min (400–550 nm, 5500 lx). Adhesion to human vascular endothelial cells or immobilized collagen was then evaluated. The influence of curcumin on chemotaxis and migration was also investigated, as well as curcumin induced alterations of α and β integrin expression. Curcumin without light exposure or light exposure without curcumin induced no alterations, whereas curcumin plus light significantly inhibited RCC adhesion, migration, and chemotaxis. This was associated with a distinct reduction of α3, α5, β1, and β3 integrins in all cell lines. Separate blocking of each of these integrin subtypes led to significant modification of tumor cell adhesion and chemotactic behavior. Combining low dosed curcumin with light considerably suppressed RCC binding activity and chemotactic movement and was associated with lowered integrin α and β subtypes. Therefore, curcumin combined with visible light holds promise for inhibiting metastatic processes in RCC.
KW  - curcumin
KW  - renal cell cancer
KW  - tumor adhesion
KW  - tumor migration
KW  - integrins
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/54475
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-544755
SN  - 2072-6694
N1  - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
VL  - 12
IS  - 2, Art. 302
SP  - 1
EP  - 16
PB  - MDPI
CY  - Basel
ER  -