TY - JOUR A1 - Höh, Robert Benedikt A1 - Flammia, Rocco Simone A1 - Hohenhorst, Lukas A1 - Sorce, Gabriele A1 - Panunzio, Andrea A1 - Tappero, Stefano A1 - Tian, Zhe A1 - Saad, Fred A1 - Gallucci, Michele A1 - Briganti, Alberto A1 - Terrone, Carlo A1 - Shariat, Shahrokh F. A1 - Graefen, Markus A1 - Tilki, Derya A1 - Antonelli, Alessandro A1 - Kosiba, Marina A1 - Mandel, Philipp A1 - Kluth, Luis A1 - Becker, Andreas A1 - Chun, Felix A1 - Karakiewicz, Pierre I. T1 - Effect of inferior vena cava tumor thrombus on overall survival in metastatic renal cell carcinoma patients treated with cytoreductive nephrectomy T2 - European urology open science N2 - Background: Survival data regarding cytoreductive nephrectomy (CN) in metastatic renal cell carcinoma (mRCC) patients according to the type and extent of tumor-associated vascular thrombus are scarce. Objective: To test for survival differences in mRCC patients treated with CN according to the type and extent of tumor-associated vascular thrombus. Design, setting, and participants: Within Surveillance, Epidemiology, and End Results Research Plus (2004–2017), we identified CN mRCC patients with renal vein (pT3a-TT) versus infradiaphragmatic inferior vena cava (IVC; pT3b) versus supradiaphragmatic IVC tumor thrombus/IVC invasion (pT3c). Outcome measurements and statistical analysis: Overall survival (OS) was addressed in Kaplan-Meier and Cox regression analyses, in addition to 3-mo landmark analyses. Results and limitations: Of 2170 mRCC patients, 1880 (87%), 204 (9%), and 86 (4%) harbored pT3a-TT, pT3b, and pT3c, respectively. The respective median OS periods were 21, 23, and 12 mo (p < 0.001). In multivariable Cox regression models, pT3c stage, but not pT3b stage, was an independent predictor of higher overall mortality (hazard ratio [HR]: 1.37; 95% confidence interval [CI]: 1.09–1.73; p = 0.007), as well as in 6-mo landmark analyses (HR: 1.36; 95% CI: 1.02–1.80; p = 0.04). In the sensitivity analysis, relying on all pT3a patients, the predictor status of pT3c stage remained unchanged (HR: 1.37; 95% CI: 1.09–1.71; p = 0.007). Limitations have to be addressed regarding the sample size and the retrospective design of the current study. Conclusions: Although overall mortality is significantly higher in pT3c mRCC patients than in their pT3b and pT3a-TT counterparts, these individuals may still expect 12-mo or better OS after CN versus virtually 2-yr OS in their pT3a and pT3b counterparts. Patient summary: In this study, we looked at the survival outcomes of metastatic renal cell carcinoma patients who presented with tumor thrombus at cytoreductive nephrectomy. Even though these patients with most advanced tumor thrombus stage demonstrated lower survival rates, the median overall survival was still 1 yr. KW - Metastatic renal cell carcinoma KW - Cytoreductive nephrectomy KW - Inferior vena cava thrombus KW - Renal vein thrombus Y1 - 2022 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/78528 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-785280 SN - 2666-1683 N1 - Gefördert durch den Open-Access-Publikationsfonds der Goethe-Universität VL - 44.2022 SP - 94 EP - 101 PB - Elsevier ScienceDirect CY - [Amsterdam] ER -