TY  - JOUR
A1  - Bergthaler, Andreas
A1  - Flatz, Lukas
A1  - Verschoor, Admar
A1  - Hegazy, Ahmed N.
A1  - Holdener, Martin
A1  - Fink, Katja
A1  - Eschli, Bruno
A1  - Merkler, Doron
A1  - Sommerstein, Rami
A1  - Horvath, Edit
A1  - Fernandez, Marylise
A1  - Fitsche, André
A1  - Senn, Beatrice M.
A1  - Verbeek, J. Sjef
A1  - Odermatt, Bernhard
A1  - Siegrist, Claire-Anne
A1  - Pinschewer, Daniel D.
T1  - Impaired antibody response causes persistence of prototypic T cell-contained virus
T2  - PLoS biology
N2  - CD8 T cells are recognized key players in control of persistent virus infections, but increasing evidence suggests that assistance from other immune mediators is also needed. Here, we investigated whether specific antibody responses contribute to control of lymphocytic choriomeningitis virus (LCMV), a prototypic mouse model of systemic persistent infection. Mice expressing transgenic B cell receptors of LCMV-unrelated specificity, and mice unable to produce soluble immunoglobulin M (IgM) exhibited protracted viremia or failed to resolve LCMV. Virus control depended on immunoglobulin class switch, but neither on complement cascades nor on Fc receptor gamma chain or Fc gamma receptor IIB. Cessation of viremia concurred with the emergence of viral envelope-specific antibodies, rather than with neutralizing serum activity, and even early nonneutralizing IgM impeded viral persistence. This important role for virus-specific antibodies may be similarly underappreciated in other primarily T cell–controlled infections such as HIV and hepatitis C virus, and we suggest this contribution of antibodies be given consideration in future strategies for vaccination and immunotherapy.
Y1  - 2009
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/6724
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-68250
SN  - 1545-7885
N1  - Copyright: © 2009 Bergthaler et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 7
IS  - (4): e1000080
SP  - 789
EP  - 799
PB  - PLoS
CY  - Lawrence, Kan.
ER  -