TY  - JOUR
A1  - Ejrnaes, Mette
A1  - Herrath, Matthias G. von
A1  - Christen, Urs
T1  - Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies
T2  - Clinical & developmental immunology
N2  - The use of neutralizing antibodies is one of the most successful methods to interfere with receptor–ligand interactions in vivo. In particular blockade of soluble inflammatory mediators or their corresponding cellular receptors was proven an effective way to regulate inflammation and/or prevent its negative consequences. However, one problem that comes along with an effective neutralization of inflammatory mediators is the general systemic immunomodulatory effect. It is, therefore, important to design a treatment regimen in a way to strike at the right place and at the right time in order to achieve maximal effects with minimal duration of immunosuppression or hyperactivation. In this review, we reflect on two examples of how short time administration of such neutralizing antibodies can block two distinct inflammatory consequences of viral infection. First, we review recent findings that blockade of IL-10/IL-10R interaction can resolve chronic viral infection and second, we reflect on how neutralization of the chemokine CXCL10 can abrogate virus-induced type 1 diabetes.
KW  - autoimmune disease
KW  - chronic infection
KW  - CXCR3
KW  - dendritic cells
KW  - LCMV
KW  - molecular mimicry
Y1  - 2009
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/6768
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-68444
SN  - 1740-2530
SN  - 1740-2522
N1  - This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
N1  - Die Publikation wurde vom Verlag zurückgezogen. Vgl. dazu: Journal of Immunology Research, 2016, Art. 2747402, doi:10.1155/2016/2747402. Der korrekte Artikel ist erschienen in: Clinical & developmental immunology, 13.2006, Nr. 2-4, S. 337-347, doi:10.1080/17402520600800721
VL  - 13
IS  - 1
SP  - 67
EP  - 77
PB  - Hindawi
CY  - New York, NY
ER  -