TY  - JOUR
A1  - Naumer, Marcus Johannes
A1  - Bosch, Jasper J. F. van den
A1  - Wibral, Michael
A1  - Kohler, Axel
A1  - Singer, Wolf
A1  - Kaiser, Jochen
A1  - Ven, Vincent van de
A1  - Muckli, Lars
T1  - Investigating human audio-visual object perception with a combination of hypothesis-generating and hypothesis-testing fMRI analysis tools
T2  - Experimental brain research
N2  - Primate multisensory object perception involves distributed brain regions. To investigate the network character of these regions of the human brain, we applied data-driven group spatial independent component analysis (ICA) to a functional magnetic resonance imaging (fMRI) data set acquired during a passive audio-visual (AV) experiment with common object stimuli. We labeled three group-level independent component (IC) maps as auditory (A), visual (V), and AV, based on their spatial layouts and activation time courses. The overlap between these IC maps served as definition of a distributed network of multisensory candidate regions including superior temporal, ventral occipito-temporal, posterior parietal and prefrontal regions. During an independent second fMRI experiment, we explicitly tested their involvement in AV integration. Activations in nine out of these twelve regions met the max-criterion (A < AV > V) for multisensory integration. Comparison of this approach with a general linear model-based region-of-interest definition revealed its complementary value for multisensory neuroimaging. In conclusion, we estimated functional networks of uni- and multisensory functional connectivity from one dataset and validated their functional roles in an independent dataset. These findings demonstrate the particular value of ICA for multisensory neuroimaging research and using independent datasets to test hypotheses generated from a data-driven analysis.
KW  - Crossmodal
KW  - Functional connectivity
KW  - Functional magnetic resonance imaging
KW  - Independent component analysis
KW  - Multisensory
KW  - Object perception
Y1  - 2011
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/30127
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-301271
SN  - 1432-1106
SN  - 0014-4819
N1  - Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
VL  - 213
SP  - 309
EP  - 320
PB  - Springer
CY  - Berlin ; Heidelberg ; New York
ER  -