TY  - JOUR
A1  - Gerber, Alexander
A1  - Bundschuh, Matthias
A1  - Klingelhöfer, Doris
A1  - Groneberg, Jan David Alexander
T1  - Gold nanoparticles : recent aspects for human toxicology
T2  - Journal of occupational medicine and toxicology
N2  - Nanoparticles (particles sized between 1 and 100 nanometers) are more and more used in all fields of science and medicine for their physicochemical properties. As gold has traditionally been considered as chemically inert and biocompatible, in particular, gold nanoparticles have been established as valuable tools in several areas of biomedical research. But in contrast to the multitude of studies that addressed the clinical use of gold nanoparticles, only little is known about potential toxicological effects such as induction of inflammatory immune responses, possible apoptotic cell death or developmental growth inhibition in embryos. Therefore the present study performed a systematic review of toxicological data, especially experimentally acquired data concerning in-vivo-toxicity, published in the PubMed. It can be stated that the data in this area of research is still largely limited. Especially, knowledge about size-, charge- and surface-chemistry dependent in-vivo-toxicity is needed to predict the hazard potential of auric nanoparticles (AuNPs) for humans.
KW  - Gold
KW  - Auric nanoparticles
KW  - Toxicology
KW  - In-vivo
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/33390
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-333908
SN  - 1745-6673
N1  - © 2013 Gerber et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 8
IS  - 32
PB  - BioMed Central
CY  - London
ER  -