TY  - JOUR
A1  - Garcés, Pilar
A1  - Vicente, Raul
A1  - Wibral, Michael
A1  - Pineda-Pardo, Jose Ángel
A1  - López, Maria Eugenia
A1  - Aurtenetxe, Sara
A1  - Marcos, Alberto
A1  - Andrés, Maria Emiliana de
A1  - Yus, Miguel
A1  - Sancho, Miguel
A1  - Maestú, Fernando
A1  - Fernández, Alberto
T1  - Brain-wide slowing of spontaneous alpha rhythms in mild cognitive impairment
T2  - Frontiers in aging neuroscience
N2  - The neurophysiological changes associated with Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) include an increase in low frequency activity, as measured with electroencephalography or magnetoencephalography (MEG). A relevant property of spectral measures is the alpha peak, which corresponds to the dominant alpha rhythm. Here we studied the spatial distribution of MEG resting state alpha peak frequency and amplitude values in a sample of 27 MCI patients and 24 age-matched healthy controls. Power spectra were reconstructed in source space with linearly constrained minimum variance beamformer. Then, 88 Regions of Interest (ROIs) were defined and an alpha peak per ROI and subject was identified. Statistical analyses were performed at every ROI, accounting for age, sex and educational level. Peak frequency was significantly decreased (p < 0.05) in MCIs in many posterior ROIs. The average peak frequency over all ROIs was 9.68 ± 0.71 Hz for controls and 9.05 ± 0.90 Hz for MCIs and the average normalized amplitude was (2.57 ± 0.59)·10(-2) for controls and (2.70 ± 0.49)·10(-2) for MCIs. Age and gender were also found to play a role in the alpha peak, since its frequency was higher in females than in males in posterior ROIs and correlated negatively with age in frontal ROIs. Furthermore, we examined the dependence of peak parameters with hippocampal volume, which is a commonly used marker of early structural AD-related damage. Peak frequency was positively correlated with hippocampal volume in many posterior ROIs. Overall, these findings indicate a pathological alpha slowing in MCI.
KW  - alpha peak
KW  - hippocampal volume
KW  - magnetoencephalography
KW  - mild cognitive impairment
KW  - slowing
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/33412
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-334122
SN  - 1663-4365
N1  - Copyright © 2013 Garcés, Vicente, Wibral, Pineda-Pardo, López, Aurtenetxe, Marcos, de Andrés, Yus, Sancho, Maestú and Fernández. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
VL  - 5
IS  - Article 100
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -