TY  - JOUR
A1  - Escott-Price, Valentina
A1  - Bellenguez, Céline
A1  - Wang, Li-San
A1  - Choi, Seung-Hoan
A1  - Harold, Denise
A1  - Jones, Lesley
A1  - Holmans, Peter
A1  - Gerrish, Amy
A1  - Vedernikov, Alexey
A1  - Richards, Alexander
A1  - DeStefano, Anita L.
A1  - Lambert, Jean-Charles
A1  - Ibrahim-Verbaas, Carla A.
A1  - Naj, Adam C.
A1  - Sims, Rebecca
A1  - Jun, Gyungah
A1  - Bis, Joshua C.
A1  - Beecham, Gary W.
A1  - Grenier-Boley, Benjamin
A1  - Russo, Giancarlo
A1  - Thornton-Wells, Tricia A.
A1  - Denning, Nicola
A1  - Smith, Albert V.
A1  - Chouraki, Vincent
A1  - Thomas, Charlene
A1  - Ikram, M. Arfan
A1  - Zelenika, Diana
A1  - Vardarajan, Badri N.
A1  - Kamatani, Yoichiro
A1  - Lin, Chiao-Feng
A1  - Schmidt, Helena
A1  - Kunkle, Brian
A1  - Dunstan, Melanie L.
A1  - Vronskaya, Maria
A1  - Johnson, Andrew D.
A1  - Ruiz, Agustin
A1  - Bihoreau, Marie-Thérèse
A1  - Reitz, Christiane
A1  - Pasquier, Florence
A1  - Hollingworth, Paul
A1  - Hanon, Olivier
A1  - Fitzpatrick, Annette L.
A1  - Buxbaum, Joseph D.
A1  - Campion, Dominique
A1  - Crane, Paul K.
A1  - Baldwin, Clinton
A1  - Becker, Tim
A1  - Gudnason, Vilmundur
A1  - Cruchaga, Carlos
A1  - Craig, David
A1  - Amin, Najaf
A1  - Berr, Claudine
A1  - Lopez, Oscar L.
A1  - Jager, Philip L. De
A1  - Deramecourt, Vincent
A1  - Johnston, Janet A.
A1  - Evans, Denis
A1  - Lovestone, Simon
A1  - Letenneur, Luc
A1  - Hernández, Isabel
A1  - Rubinsztein, David C.
A1  - Eiriksdottir, Gudny
A1  - Sleegers, Kristel
A1  - Goate, Alison M.
A1  - Fiévet, Nathalie
A1  - Huentelman, Matthew J.
A1  - Gill, Michael
A1  - Brown, Kristelle
A1  - Kamboh, M. Ilyas
A1  - Keller, Lina
A1  - Barberger-Gateau, Pascale
A1  - McGuinness, Bernadette
A1  - Larson, Eric B.
A1  - Myers, Amanda J.
A1  - Dufouil, Carole
A1  - Todd, Stephen
A1  - Wallon, David
A1  - Love, Seth
A1  - Rogaeva, Ekaterina
A1  - Gallacher, John
A1  - St George-Hyslop, Peter
A1  - Clarimon, Jordi
A1  - Lleo, Alberto
A1  - Bayer, Anthony
A1  - Tsuang, Debby W.
A1  - Yu, Lei
A1  - Tsolaki, Magda
A1  - Bossù, Paola
A1  - Spalletta, Gianfranco
A1  - Proitsi, Petra
A1  - Collinge, John
A1  - Sorbi, Sandro
A1  - Sanchez Garcia, Florentino
A1  - Fox, Nick C.
A1  - Hardy, John
A1  - Deniz Naranjo, Maria Candida
A1  - Bosco, Paolo
A1  - Clarke, Robert
A1  - Brayne, Carol
A1  - Galimberti, Daniela
A1  - Scarpini, Elio
A1  - Bonuccelli, Ubaldo
A1  - Mancuso, Michelangelo
A1  - Siciliano, Gabriele
A1  - Moebus, Susanne
A1  - Mecocci, Patrizia
A1  - Del Zompo, Maria
A1  - Maier, Wolfgang
A1  - Hampel, Harald
A1  - Pilotto, Alberto
A1  - Frank-García, Ana
A1  - Panza, Francesco
A1  - Solfrizzi, Vincenzo
A1  - Caffarra, Paolo
A1  - Nacmias, Benedetta
A1  - Perry, William
A1  - Mayhaus, Manuel
A1  - Lannfelt, Lars
A1  - Hakonarson, Hakon
A1  - Pichler, Sabrina
A1  - Carrasquillo, Minerva M.
A1  - Ingelsson, Martin
A1  - Beekly, Duane
A1  - Alvarez, Victoria
A1  - Zou, Fanggeng
A1  - Valladares, Otto
A1  - Younkin, Steven G.
A1  - Coto, Eliecer
A1  - Hamilton-Nelson, Kara L.
A1  - Gu, Wei
A1  - Razquin, Cristina
A1  - Pastor, Pau
A1  - Mateo, Ignacio
A1  - Owen, Michael J.
A1  - Faber, Kelley M.
A1  - Jonsson, Palmi V.
A1  - Combarros, Onofre
A1  - O'Donovan, Michael C.
A1  - Cantwell, Laura B.
A1  - Soininen, Hilkka
A1  - Blacker, Deborah
A1  - Mead, Simon
A1  - Mosley, Thomas H.
A1  - Bennett, David A.
A1  - Harris, Tamara B.
A1  - Fratiglioni, Laura
A1  - Holmes, Clive
A1  - Bruijn, Renee F. A. G. de
A1  - Passmore, Peter
A1  - Montine, Thomas J.
A1  - Bettens, Karolien
A1  - Rotter, Jerome I.
A1  - Brice, Alexis
A1  - Morgan, Kevin
A1  - Foroud, Tatiana M.
A1  - Kukull, Walter A.
A1  - Hannequin, Didier
A1  - Powell, John F.
A1  - Nalls, Michael A.
A1  - Ritchie, Karen
A1  - Lunetta, Kathryn L.
A1  - Kauwe, John S. K.
A1  - Boerwinkle, Eric
A1  - Riemenschneider, Matthias
A1  - Boada, Mercè
A1  - Hiltunen, Mikko
A1  - Martin, Eden R.
A1  - Schmidt, Reinhold
A1  - Rujescu, Dan
A1  - Dartigues, Jean-François
A1  - Mayeux, Richard
A1  - Tzourio, Christophe
A1  - Hofman, Albert
A1  - Nöthen, Markus Maria
A1  - Graff, Caroline
A1  - Psaty, Bruce M.
A1  - Haines, Jonathan L.
A1  - Lathrop, Mark
A1  - Pericak-Vance, Margaret Ann
A1  - Launer, Lenore J.
A1  - Broeckhoven, Christine Van
A1  - Farrer, Lindsay A.
A1  - Duijn, Cornelia M. van
A1  - Ramirez, Alfredo
A1  - Seshadri, Sudha
A1  - Schellenberg, Gerard D.
A1  - Amouyel, Philippe
A1  - Williams, Julie
T1  - Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease
T2  - PLoS One
N2  - Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls.
Principal findings: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4×10−6) and 14 (IGHV1-67 p = 7.9×10−8) which indexed novel susceptibility loci.
Significance: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/34220
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-342205
SN  - 1932-6203
N1  - This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
VL  - 9
IS  - (6):e94661
PB  - PLoS
CY  - Lawrence, Kan.
ER  -