TY  - JOUR
A1  - Ouahrouch, Abdelaaziz
A1  - Taourirte, Moha
A1  - Engels, Joachim W.
A1  - Benjelloun, Soumaya
A1  - Lazrek, Hassan B.
T1  - Synthesis of new 1,2,3-triazol-4-yl-quinazoline nucleoside and acyclonucleoside analogues
T2  - Molecules
N2  - In this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-quinazoline ribonucleosides or acyclonucleosides by means of 1,3-dipolar cycloaddition between various O or N-alkylated propargyl-quinazoline and 1'-azido-2',3',5'-tri-O-benzoylribose or activated alkylating agents under microwave conditions. None of the compounds selected showed significant anti-HCV activity in vitro.
KW  - quinazoline ribonucleosides
KW  - 1,2,3-triazole-acyclonucleosides
KW  - Huisgen cycloaddition
KW  - quinazolinone alkylation
KW  - HCV
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/34308
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-343083
SN  - 1420-3049
N1  - © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
VL  - 19
IS  - 3
SP  - 3638
EP  - 3653
PB  - MDPI
CY  - Basel
ER  -