TY  - JOUR
A1  - Pleli, Thomas
A1  - Martin, Daniel
A1  - Kronenberger, Bernd
A1  - Brunner, Friederike
A1  - Köberle, Verena
A1  - Grammatikos, Georgios
A1  - Farnik, Harald
A1  - Martinez, Yolanda
A1  - Finkelmeier, Fabian
A1  - Labocha, Sandra
A1  - Ferreirós Bouzas, Nerea
A1  - Zeuzem, Stefan
A1  - Piiper, Albrecht
A1  - Waidmann, Oliver
T1  - Serum autotaxin is a parameter for the severity of liver cirrhosis and overall survival in patients with liver cirrhosis : a prospective cohort study
T2  - PLoS One
N2  - Background: Autotaxin (ATX) and its product lysophosphatidic acid (LPA) are considered to be involved in the development of liver fibrosis and elevated levels of serum ATX have been found in patients with hepatitis C virus associated liver fibrosis. However, the clinical role of systemic ATX in the stages of liver cirrhosis was unknown. Here we investigated the relation of ATX serum levels and severity of cirrhosis as well as prognosis of cirrhotic patients.
Methods: Patients with liver cirrhosis were prospectively enrolled and followed until death, liver transplantation or last contact. Blood samples drawn at the day of inclusion in the study were assessed for ATX content by an enzyme-linked immunosorbent assay. ATX levels were correlated with the stage as well as complications of cirrhosis. The prognostic value of ATX was investigated by uni- and multivariate Cox regression analyses. LPA concentration was determined by liquid chromatography-tandem mass spectrometry.
Results: 270 patients were enrolled. Subjects with liver cirrhosis showed elevated serum levels of ATX as compared to healthy subjects (0.814±0.42 mg/l vs. 0.258±0.40 mg/l, P<0.001). Serum ATX levels correlated with the Child-Pugh stage and the MELD (model of end stage liver disease) score and LPA levels (r = 0.493, P = 0.027). Patients with hepatic encephalopathy (P = 0.006), esophageal varices (P = 0.002) and portal hypertensive gastropathy (P = 0.008) had higher ATX levels than patients without these complications. Low ATX levels were a parameter independently associated with longer overall survival (hazard ratio 0.575, 95% confidence interval 0.365–0.905, P = 0.017).
Conclusion: Serum ATX is an indicator for the severity of liver disease and the prognosis of cirrhotic patients.
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/34729
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-347290
SN  - 1932-6203
N1  - Copyright: © 2014 Pleli et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 9
IS  - (7):e103532
PB  - PLoS
CY  - Lawrence, Kan.
ER  -