TY  - JOUR
A1  - Meyer, Claus
A1  - Hofmann, J
A1  - Burmeister, Thomas
A1  - Gröger, D
A1  - Park, TS
A1  - Emerenciano, M
A1  - Pombo de Oliveira, M
A1  - Renneville, A
A1  - Macintyre, E
A1  - Cavé, H
A1  - Clappier, E
A1  - Mass-Malo, K
A1  - Zuna, J
A1  - Trka, J
A1  - De Braekeleer, E
A1  - De Braekeleer, M
A1  - Oh, SH
A1  - Tsaur, G
A1  - Fechina, L
A1  - van der Velden, VH
A1  - van Dongen, JJ
A1  - Delabesse, E
A1  - Binato, R
A1  - Silva, ML
A1  - Kustanovich, A
A1  - Aleinikova, O
A1  - Harris, MH
A1  - Lund-Aho, T
A1  - Juvonen, V
A1  - Heidenreich, Olaf Torben
A1  - Vormoor, J
A1  - Choi, WW
A1  - Jarosova, M
A1  - Kolenova, A
A1  - Bueno, C
A1  - Menendez, P
A1  - Wehner, S
A1  - Eckert, C
A1  - Talmant, P
A1  - Tondeur, S
A1  - Lippert, E
A1  - Launay, E
A1  - Henry, C
A1  - Ballerini, P
A1  - Lapillone, H
A1  - Callanan, MB
A1  - Cayuela, JM
A1  - Herbaux, C
A1  - Cazzaniga, G
A1  - Kakadiya, PM
A1  - Bohlander, Stefan Klaus
A1  - Ahlmann, M
A1  - Choi, JR
A1  - Gameiro, P
A1  - Lee, DS
A1  - Krauter, J
A1  - Cornillet-Lefebvre, P
A1  - Te Kronnie, G
A1  - Schäfer, BW
A1  - Kubetzko, S
A1  - Alonso, CN
A1  - zur Stadt, U
A1  - Sutton, R
A1  - Venn, NC
A1  - Izraeli, S
A1  - Trakhtenbrot, L
A1  - Madsen, HO
A1  - Archer, P
A1  - Hancock, J
A1  - Cerveira, N
A1  - Teixeira, MR
A1  - Lo Nigro, L
A1  - Möricke, A
A1  - Stanulla, M
A1  - Schrappe, M
A1  - Sedék, L
A1  - Szczepański, T
A1  - Zwaan, CM
A1  - Coenen, EA
A1  - van den Heuvel-Eibrink, MM
A1  - Strehl, S
A1  - Dworzak, Michael N.
A1  - Panzer-Grümayer, Renate
A1  - Dingermann, Theodor
A1  - Klingebiel, Thomas
A1  - Marschalek, Rolf
T1  - The MLL recombinome of acute leukemias in 2013
T2  - Leukemia
N2  - Chromosomal rearrangements of the human MLL (mixed lineage leukemia) gene are associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We used long-distance inverse-polymerase chain reaction to characterize the chromosomal rearrangement of individual acute leukemia patients. We present data of the molecular characterization of 1590 MLL-rearranged biopsy samples obtained from acute leukemia patients. The precise localization of genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and novel TPGs identified. All patients were classified according to their gender (852 females and 745 males), age at diagnosis (558 infant, 416 pediatric and 616 adult leukemia patients) and other clinical criteria. Combined data of our study and recently published data revealed a total of 121 different MLL rearrangements, of which 79 TPGs are now characterized at the molecular level. However, only seven rearrangements seem to be predominantly associated with illegitimate recombinations of the MLL gene (~ 90%): AFF1/AF4, MLLT3/AF9, MLLT1/ENL, MLLT10/AF10, ELL, partial tandem duplications (MLL PTDs) and MLLT4/AF6, respectively. The MLL breakpoint distributions for all clinical relevant subtypes (gender, disease type, age at diagnosis, reciprocal, complex and therapy-induced translocations) are presented. Finally, we present the extending network of reciprocal MLL fusions deriving from complex rearrangements.
KW  - MLL
KW  - chromosomal translocations
KW  - translocation partner genes
KW  - acute leukemia
KW  - ALL
KW  - AML
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/35550
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-355505
SN  - 1476-5551
SN  - 0887-6924
N1  - Copyright © 2013 Macmillan Publishers Limited This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
VL  - 27
IS  - 11
SP  - 2165
EP  - 2176
PB  - Nature Publ. Group
CY  - Basingstoke
ER  -