TY  - JOUR
A1  - Kippenberger, Stefan
A1  - Zöller, Nadja Nicole
A1  - Kleemann, Johannes
A1  - Müller, Jutta
A1  - Kaufmann, Roland
A1  - Hofmann, Matthias
A1  - Bernd, August
A1  - Meissner, Markus
A1  - Valesky, Eva Maria
T1  - STAT6-dependent collagen synthesis in human fibroblasts is induced by bovine milk
T2  - PLoS One
N2  - Since the domestication of the urus, 10.000 years ago, mankind utilizes bovine milk for different purposes. Besides usage as a nutrient also the external application of milk on skin has a long tradition going back to at least the ancient Aegypt with Cleopatra VII as a great exponent. In order to test whether milk has impact on skin physiology, cultures of human skin fibroblasts were exposed to commercial bovine milk. Our data show significant induction of proliferation by milk (max. 2,3-fold, EC50: 2,5% milk) without toxic effects. Surprisingly, bovine milk was identified as strong inducer of collagen 1A1 synthesis at both, the protein (4-fold, EC50: 0,09% milk) and promoter level. Regarding the underlying molecular pathways, we show functional activation of STAT6 in a p44/42 and p38-dependent manner. More upstream, we identified IGF-1 and insulin as key factors responsible for milk-induced collagen synthesis. These findings show that bovine milk contains bioactive molecules that act on human skin cells. Therefore, it is tempting to test the herein introduced concept in treatment of atrophic skin conditions induced e.g. by UV light or corticosteroids.
Y1  - 2015
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/37983
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-379836
SN  - 1932-6203
N1  - Copyright: © 2015 Kippenberger et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
VL  - 10
IS  - (7): e0131783
SP  - 1
EP  - 15
PB  - PLoS
CY  - Lawrence, Kan.
ER  -