TY  - JOUR
A1  - Andreas, Martin
A1  - Wallner, Stephanie
A1  - Rützler, Kurt
A1  - Wiedemann, Dominik
A1  - Ehrlich, Marek
A1  - Heinze, Georg
A1  - Binder, Thomas
A1  - Moritz, Anton
A1  - Hiesmayr, Michael J.
A1  - Kocher, Alfred
A1  - Laufer, Günther
T1  - Comparable long-term results for porcine and pericardial prostheses after isolated aortic valve replacement
T2  - European Journal of Cardio-Thoracic Surgery
N2  - OBJECTIVES: Outcome of aortic valve replacement may be influenced by the choice of bioprosthesis. Pericardial heart valves are described to have a favourable haemodynamic profile compared with porcine valves, although the clinical notability of this finding is still controversially debated. Herein, we compared the long-term results of two commonly implanted bioprosthesis at a single centre.
METHODS: All consecutive patients undergoing isolated aortic valve replacement with either a Carpentier-Edwards Magna pericardial prosthesis or a Medtronic Mosaic porcine prosthesis between 2002 and 2008 were analysed regarding preoperative characteristics, short- and long-term survival, valve-related complications and echocardiographic findings.
RESULTS: The Medtronic Mosaic was implanted in 163 patients and the Carpentier-Edwards Magna in 295 patients. The sizes of implanted valves were 22.4 ± 1.5 mm for the Mosaic and 21.8 ± 1.8 mm for the Magna (P = 0.001). The long-term survival rate was 76 and 56% after 5 and 10 years for the Medtronic Mosaic, which was comparable with the Carpentier-Edwards Magna (77 and 57%; P = 0.92). Overall long-term survival was comparable with an age- and sex-matched Austrian general population for both groups. Valve-related adverse events were similar between groups. The postoperative mean transvalvular gradient was significantly increased in the Mosaic group (24 ± 9 mmHg vs 17 ± 7 mmHg; P < 0.001).
CONCLUSIONS: Both types of aortic bioprostheses offer excellent results after isolated aortic valve replacement. Despite relevant differences in gradients, long-term survival was comparable with the expected normal survival for both bioprostheses. Patients with a porcine heart valve had a higher postoperative transvalvular gradient.
KW  - Aortic valve replacement
KW  - Biological heart valves
KW  - Bioprosthesis
KW  - Survival analysis
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/31079
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-310798
SN  - 1873-734X
SN  - 1010-7940
N1  - © The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
VL  - 48
SP  - 557
EP  - 561
PB  - Oxford Univ. Press
CY  - Oxford
ER  -